Rohrschneider Klaus
Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.
Invest Ophthalmol Vis Sci. 2004 Sep;45(9):3257-8. doi: 10.1167/iovs.03-1157.
To evaluate whether the distance between optic nerve head and fovea in healthy eyes determined by scanning laser ophthalmoscope may facilitate estimation of the location of the fovea relative to the optic disc in patients with macular disease.
The angular distance was measured, in horizontal and vertical directions, between the center of the optic nerve head and the fovea in 104 eyes of 104 healthy probands. For additional evaluation of intraindividual variation in 70 of these persons the contralateral eye was measured as well.
The distance between the optic disc and the fovea differed vertically more than horizontally (-1.5 +/- 0.9 degrees [-3.65 to +0.65 degrees ] vs. 15.5 +/- 1.1 degrees [13.0-17.9 degrees ]). There was a mean angle between the fovea and the center of the optic disc versus the horizon of -5.6 +/- 3.3 degrees. The intraindividual difference between right and left eyes was markedly lower, with average angles being 0.2 +/- 1.3 degrees vertically and 0.0 +/- 1.1 degrees horizontally.
The distance between the optic nerve head and the fovea does not allow for a meaningful determination of the location of the fovea in eyes in which morphologic changes have occurred. The angle of rotation of the fovea relatively to the center of the optic nerve head is relatively stable. Therefore, the size of a central scotoma can be determined by movement of the blind spot according to the change of the preferred retinal locus (PRL). In addition, the knowledge of the location of the fovea enables determination of the position in the contralateral eye of the same patient.
评估通过扫描激光检眼镜测定健康眼睛中视神经乳头与黄斑中心凹之间的距离，是否有助于估计黄斑疾病患者黄斑中心凹相对于视盘的位置。
测量了104名健康受试者的104只眼中视神经乳头中心与黄斑中心凹在水平和垂直方向上的角距离。为了进一步评估其中70人的个体内差异，还测量了对侧眼。
视盘与黄斑中心凹之间的垂直距离差异大于水平距离（-1.5±0.9度[-3.65至+0.65度]对15.5±1.1度[13.0 - 17.9度]）。黄斑中心凹与视盘中心相对于地平线的平均角度为-5.6±3.3度。左右眼之间的个体内差异明显更小，垂直平均角度为0.2±1.3度，水平平均角度为0.0±1.1度。
在已发生形态学改变的眼睛中，视神经乳头与黄斑中心凹之间的距离无法用于有意义地确定黄斑中心凹的位置。黄斑中心凹相对于视神经乳头中心的旋转角度相对稳定。因此，中央暗点的大小可以根据 Preferred Retinal Locus（PRL）的变化，通过盲点的移动来确定。此外，了解黄斑中心凹的位置有助于确定同一患者对侧眼中的位置。
