• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
T2182C mutation in 23S rRNA is associated with clarithromycin resistance in Helicobacter pylori isolates obtained in Bangladesh.在孟加拉国分离出的幽门螺杆菌菌株中，23S rRNA中的T2182C突变与克拉霉素耐药性相关。
Antimicrob Agents Chemother. 2004 Sep;48(9):3567-9. doi: 10.1128/AAC.48.9.3567-3569.2004.
2
Gene mutations of 23S rRNA associated with clarithromycin resistance in Helicobacter pylori strains isolated from Korean patients.从韩国患者分离出的幽门螺杆菌菌株中与克拉霉素耐药性相关的23S rRNA基因突变。
J Microbiol Biotechnol. 2008 Sep;18(9):1584-9.
3
Mutations in the 23S rRNA gene of clarithromycin-resistant Helicobacter pylori from Japan.来自日本的克拉霉素耐药幽门螺杆菌23S rRNA基因中的突变
Int J Antimicrob Agents. 2007 Sep;30(3):250-4. doi: 10.1016/j.ijantimicag.2007.04.009. Epub 2007 Jun 21.
4
Novel genotypes in Helicobacter pylori involving domain V of the 23S rRNA gene.幽门螺杆菌中涉及23S rRNA基因第五结构域的新型基因型。
Helicobacter. 2007 Oct;12(5):505-9. doi: 10.1111/j.1523-5378.2007.00506.x.
5
[A2144G is the main mutation in the 23S rRNA gene of Helicobacter pylori associated with clarithromycin resistance].A2144G是幽门螺杆菌23S rRNA基因中与克拉霉素耐药相关的主要突变。
Genetika. 2005 Oct;41(10):1338-44.
6
Rapid detection of clarithromycin resistance in Helicobacter pylori using a PCR-based denaturing HPLC assay.使用基于聚合酶链反应的变性高效液相色谱分析法快速检测幽门螺杆菌对克拉霉素的耐药性。
J Antimicrob Chemother. 2006 Jan;57(1):71-8. doi: 10.1093/jac/dki406. Epub 2005 Nov 11.
7
Mutations in the 23S rRNA gene of Helicobacter pylori associated with clarithromycin resistance.幽门螺杆菌23S rRNA基因的突变与克拉霉素耐药性相关。
J Korean Med Sci. 2002 Oct;17(5):599-603. doi: 10.3346/jkms.2002.17.5.599.
8
[Detection of Helicobacter pylori 23S rRNA gene mutation associated with clarithromycin resistance and its clinical applicability].
Nihon Rinsho. 1999 Jan;57(1):87-92.
9
Characterization of 23S rRNA gene mutation in primary and secondary clarithromycin-resistant Helicobacter pylori strains from East China.华东地区原发性和继发性克拉霉素耐药幽门螺杆菌菌株中23S rRNA基因突变的特征分析
Turk J Gastroenterol. 2013;24(1):5-9. doi: 10.4318/tjg.2013.0525.
10
High prevalence of clarithromycin-resistant Helicobacter pylori strains and risk factors associated with resistance in Madrid, Spain.西班牙马德里地区克拉霉素耐药幽门螺杆菌菌株的高流行率及其耐药相关危险因素。
J Clin Microbiol. 2010 Oct;48(10):3703-7. doi: 10.1128/JCM.00144-10. Epub 2010 Jul 28.

引用本文的文献

1
Detection of Clarithromycin Resistance in Helicobacter pylori Using MmaxSure™ H. pylori & ClaR Assay.使用 MmaxSure™ H. pylori & ClaR 检测试剂盒检测幽门螺杆菌克拉霉素耐药性。
Dig Dis. 2024;42(4):292-298. doi: 10.1159/000538655. Epub 2024 Apr 10.
2
The Role of Probiotics in the Eradication of Helicobacter pylori and Overall Impact on Management of Peptic Ulcer: A Study Involving Patients Undergoing Triple Therapy in Bangladesh.益生菌在根除幽门螺杆菌中的作用及对消化性溃疡治疗的总体影响：一项针对孟加拉国接受三联疗法患者的研究
Cureus. 2024 Mar 16;16(3):e56283. doi: 10.7759/cureus.56283. eCollection 2024 Mar.
3
Molecular Characterization and Mutational Analysis of Clarithromycin- and Levofloxacin-Resistance Genes in from Gastric Biopsies in Southern Croatia.来自克罗地亚南部胃活检样本中克拉霉素和左氧氟沙星耐药基因的分子特征和突变分析。
Int J Mol Sci. 2023 Sep 26;24(19):14560. doi: 10.3390/ijms241914560.
4
Antibiotic Resistance Rates for in Rural Arizona: A Molecular-Based Study.亚利桑那州农村地区的抗生素耐药率：一项基于分子的研究。
Microorganisms. 2023 Sep 12;11(9):2290. doi: 10.3390/microorganisms11092290.
5
Antibiotic Resistance, Susceptibility Testing and Stewardship in Infection.感染中的抗生素耐药性、药敏试验和管理
Int J Mol Sci. 2023 Jul 20;24(14):11708. doi: 10.3390/ijms241411708.
6
Role of AlgC and GalU in the Intrinsic Antibiotic Resistance of .AlgC和GalU在……的固有抗生素抗性中的作用 。（原文句子不完整）
Infect Drug Resist. 2023 Mar 29;16:1839-1847. doi: 10.2147/IDR.S403046. eCollection 2023.
7
Mutations Related to Antibiotics Resistance in Clinical Isolates from Bangladesh.孟加拉国临床分离株中与抗生素耐药性相关的突变
Antibiotics (Basel). 2023 Jan 31;12(2):279. doi: 10.3390/antibiotics12020279.
8
Real-time PCR detection of clarithromycin resistance in Thrace, Greece.希腊色雷斯地区克拉霉素耐药性的实时聚合酶链反应检测
Hippokratia. 2021 Apr-Jun;25(2):51-55.
9
A Survey of Antibiotic-Resistant Genotypes and Strain Lineages by Whole-Genome Sequencing in China.中国全基因组测序对抗生素耐药基因型和菌株谱系的调查。
Antimicrob Agents Chemother. 2022 Jun 21;66(6):e0218821. doi: 10.1128/aac.02188-21. Epub 2022 Jun 2.
10
Characterization of Domain V Mutations in Clinical Isolates of in Pakistan and Their Effect on Clarithromycin MIC.巴基斯坦临床分离株中Ⅴ结构域突变的特征及其对克拉霉素最低抑菌浓度的影响
Infect Drug Resist. 2021 Aug 24;14:3393-3403. doi: 10.2147/IDR.S306878. eCollection 2021.

本文引用的文献

1
New site of modification of 23S rRNA associated with clarithromycin resistance of Helicobacter pylori clinical isolates.与幽门螺杆菌临床分离株克拉霉素耐药性相关的23S rRNA新修饰位点。
Antimicrob Agents Chemother. 2002 Dec;46(12):3765-9. doi: 10.1128/AAC.46.12.3765-3769.2002.
2
Mutations in the 23S rRNA gene of Helicobacter pylori associated with clarithromycin resistance.幽门螺杆菌23S rRNA基因的突变与克拉霉素耐药性相关。
J Korean Med Sci. 2002 Oct;17(5):599-603. doi: 10.3346/jkms.2002.17.5.599.
3
Antibiotic resistance of Helicobacter pylori strains in Japanese children.日本儿童幽门螺杆菌菌株的抗生素耐药性
J Clin Microbiol. 2002 Feb;40(2):649-53. doi: 10.1128/JCM.40.2.649-653.2002.
4
Assessment of clarithromycin-resistant Helicobacter pylori among patients in Shanghai and Guangzhou, China, by primer-mismatch PCR.运用引物错配聚合酶链反应对中国上海和广州患者中耐克拉霉素的幽门螺杆菌进行评估。
J Clin Microbiol. 2002 Jan;40(1):259-61. doi: 10.1128/JCM.40.1.259-261.2002.
5
Accurate prediction of macrolide resistance in Helicobacter pylori by a PCR line probe assay for detection of mutations in the 23S rRNA gene: multicenter validation study.通过用于检测23S rRNA基因突变的PCR线探针检测法准确预测幽门螺杆菌对大环内酯类药物的耐药性：多中心验证研究
Antimicrob Agents Chemother. 2001 May;45(5):1500-4. doi: 10.1128/AAC.45.5.1500-1504.2001.
6
Comparison of the Etest and the NCCLS-approved agar dilution method to detect metronidazole and clarithromycin resistant Helicobacter pylori.比较Etest法与美国国家临床实验室标准委员会（NCCLS）认可的琼脂稀释法检测耐甲硝唑和克拉霉素幽门螺杆菌的效果。
Int J Antimicrob Agents. 2001 Jan;17(1):39-44. doi: 10.1016/s0924-8579(00)00320-4.
7
Role of antimicrobial susceptibility testing on efficacy of triple therapy in Helicobacter pylori eradication.
Aliment Pharmacol Ther. 2000 Dec;14(12):1639-43. doi: 10.1046/j.1365-2036.2000.00870.x.
8
Clarithromycin-resistance and point mutations in the 23S rRNA gene in Helicobacter pylori isolates from Japan.日本幽门螺杆菌分离株中23S rRNA基因的克拉霉素耐药性及点突变
J Gastroenterol Hepatol. 2000 Aug;15(8):906-9. doi: 10.1046/j.1440-1746.2000.02072.x.
9
Clarithromycin resistance stability in Helicobacter pylori: influence of the MIC and type of mutation in the 23S rRNA.幽门螺杆菌中克拉霉素耐药性的稳定性：23S rRNA中最低抑菌浓度及突变类型的影响
J Antimicrob Chemother. 2000 Oct;46(4):613-6. doi: 10.1093/jac/46.4.613.
10
PCR using 3'-mismatched primers to detect A2142C mutation in 23S rRNA conferring resistance to clarithromycin in Helicobacter pylori clinical isolates.使用3'-错配引物的聚合酶链反应检测幽门螺杆菌临床分离株中23S rRNA赋予对克拉霉素耐药性的A2142C突变。
J Clin Microbiol. 2000 Feb;38(2):923-5. doi: 10.1128/JCM.38.2.923-925.2000.

在孟加拉国分离出的幽门螺杆菌菌株中，23S rRNA中的T2182C突变与克拉霉素耐药性相关。

T2182C mutation in 23S rRNA is associated with clarithromycin resistance in Helicobacter pylori isolates obtained in Bangladesh.

作者信息

Khan Rasel, Nahar Shamsun, Sultana Jinath, Ahmad Mian Mashhud, Rahman Motiur

机构信息

Laboratory Sciences Division, ICDDR, B, GPO Box 128, Dhaka 1000, Bangladesh.

出版信息

Antimicrob Agents Chemother. 2004 Sep;48(9):3567-9. doi: 10.1128/AAC.48.9.3567-3569.2004.

DOI:10.1128/AAC.48.9.3567-3569.2004
PMID:15328128
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC514733/
Abstract

Twelve clarithromycin-resistant (MIC, > or = 1 microg/ml) Helicobacter pylori isolates were analyzed for point mutations in the 23S rRNA gene. Sequence analysis of all of the resistant isolates revealed a T-to-C transition mutation at position 2182. Transformation experiments confirmed that a single T-to-C transition mutation at position 2182 is associated with clarithromycin resistance.

摘要

对12株耐克拉霉素（最低抑菌浓度，≥1微克/毫升）的幽门螺杆菌分离株进行了23S rRNA基因点突变分析。对所有耐药分离株的序列分析显示，在2182位存在T到C的转换突变。转化实验证实，2182位的单个T到C转换突变与克拉霉素耐药性相关。