在孟加拉国分离出的幽门螺杆菌菌株中，23S rRNA中的T2182C突变与克拉霉素耐药性相关。
T2182C mutation in 23S rRNA is associated with clarithromycin resistance in Helicobacter pylori isolates obtained in Bangladesh.
作者信息
Khan Rasel, Nahar Shamsun, Sultana Jinath, Ahmad Mian Mashhud, Rahman Motiur
机构信息
Laboratory Sciences Division, ICDDR, B, GPO Box 128, Dhaka 1000, Bangladesh.
出版信息
Antimicrob Agents Chemother. 2004 Sep;48(9):3567-9. doi: 10.1128/AAC.48.9.3567-3569.2004.
Abstract
Twelve clarithromycin-resistant (MIC, > or = 1 microg/ml) Helicobacter pylori isolates were analyzed for point mutations in the 23S rRNA gene. Sequence analysis of all of the resistant isolates revealed a T-to-C transition mutation at position 2182. Transformation experiments confirmed that a single T-to-C transition mutation at position 2182 is associated with clarithromycin resistance.
摘要
对12株耐克拉霉素（最低抑菌浓度，≥1微克/毫升）的幽门螺杆菌分离株进行了23S rRNA基因点突变分析。对所有耐药分离株的序列分析显示，在2182位存在T到C的转换突变。转化实验证实，2182位的单个T到C转换突变与克拉霉素耐药性相关。
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