Heffner R R, Barron S A
J Neurol Sci. 1978 Oct;38(3):295-315. doi: 10.1016/0022-510x(78)90137-5.
The effects of early ischemia were studied in the anterior tibial muscle of Sprague-Dawley rats after 2--24 hr of tourniquet compression at the thigh. Ragged-red fibers, moth-eaten fibers, cores and targets were seen in tissue examined by enzyme histochemistry and electron microscopy. Giant mitochondria, abnormalities of cristal arrangement, crystalloids, osmiophilic inclusion bodies and myeloid figures were dominant features of the mitochondrial reaction. The results of this experiment indicate that early ischemia induces a variety of changes described in other neuromuscular conditions such as dystrophy and the "mitochondrial myopathies". The pathogenesis of these changes and their relationship to human disease of muscle is discussed.
在对Sprague-Dawley大鼠大腿进行2至24小时止血带压迫后，研究了其胫前肌早期缺血的影响。通过酶组织化学和电子显微镜检查组织时，可见破碎红纤维、虫蚀状纤维、核心和靶形改变。巨大线粒体、嵴排列异常、晶体、嗜锇包涵体和髓样结构是线粒体反应的主要特征。本实验结果表明，早期缺血会引发多种在其他神经肌肉疾病（如营养不良和“线粒体肌病”）中所描述的变化。文中还讨论了这些变化的发病机制及其与人类肌肉疾病的关系。
