Yie Shang-mian, Li Liang-hong, Li Yue-mei, Librach Clifford
Department of Obstetrics and Gynecology, Division of Reproductive Sciences, Toronto General Hospital Research Institute, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.
Am J Obstet Gynecol. 2004 Aug;191(2):525-9. doi: 10.1016/j.ajog.2004.01.033.
The aim of this study were to determine whether soluble human leukocyte antigen-G protein levels in serum and/or human leukocyte antigen protein in placental tissues differ between women with preeclampsia versus uncomplicated pregnancies. Study design human leukocyte antigen-G levels were determined with the use of a specific enzyme-linked immunosorbent assay in 20 subjects with preeclampsia and 14 normal control subjects.
Both serum and placental human leukocyte antigen-G levels were decreased significantly in the preeclampsia group (median, 0.026 microg/mL in serum; median, 0.026 microg/mg protein in placenta), in comparison with normal pregnant women (median, 0.093 microg/mL in serum; median, 0.088 microg/mg protein in placenta; P=.0112 and P=.0406, respectively). There was a significant correlation between serum and placental human leukocyte antigen-G levels (r=0.603; P=0.0002).
The reduced expression of placental human leukocyte antigen-G and reduced release of this protein into the maternal circulation in preeclampsia may alter the maternal-fetal immune relationship and thus be involved in the cause of this disorder.
本研究旨在确定子痫前期患者与正常妊娠女性相比，血清中可溶性人类白细胞抗原-G蛋白水平和/或胎盘组织中人类白细胞抗原蛋白水平是否存在差异。研究设计：采用特异性酶联免疫吸附测定法，对20例子痫前期患者和14例正常对照者测定人类白细胞抗原-G水平。
与正常孕妇相比，子痫前期组血清和胎盘组织中人类白细胞抗原-G水平均显著降低（血清中位数为0.026μg/mL；胎盘组织中蛋白质中位数为0.026μg/mg；P值分别为0.0112和0.0406）。血清和胎盘组织中人类白细胞抗原-G水平之间存在显著相关性（r=0.603；P=0.0002）。
子痫前期患者胎盘组织中人类白细胞抗原-G表达降低，且该蛋白向母体循环中的释放减少，可能改变母胎免疫关系，从而参与该疾病的发病机制。
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