Knuiman Matthew W, Watts Gerald F, Divitini Mark L
School of Population Health, University of Western Australia, Crawley, Western Australia.
Ann Epidemiol. 2004 Oct;14(9):627-32. doi: 10.1016/j.annepidem.2003.09.017.
To investigate the relationship between serum sialic acid level and risk of coronary heart disease (CHD) and stroke in men and women without diagnosed cardiovascular disease.
A prospective case-cohort study over the period 1981 to 1998 involving 151 CHD cases, 87 stroke cases, and a random sub-cohort of 340 was used. Sialic acid levels were determined by enzymatic method from frozen serum. Cox proportional hazards regression was used to estimate the relative risks of CHD and stroke for sialic acid tertiles and for continuous sialic acid level after adjustment for age, blood pressure, body mass index, cholesterol, triglycerides, diabetes, and smoking.
The multivariate-adjusted relative risk of CHD associated with a 25 mg/dl increase in sialic acid was 1.22 (95% CI: 1.02-1.45) overall, 1.40 (95% CI: 1.11-1.76) in women, and 1.06 (95% CI: 0.82-1.37) in men. The overall relative risk for stroke was 1.13 (95% CI: 0.87-1.46) and for CHD and stroke combined it was 1.17 (95% CI: 0.99-1.37)
Serum sialic acid may be a long-term predictor of CHD events in adults (especially women) who are currently clinically free of cardiovascular disease. Further studies are needed to determine whether this association can be explained by sialic acid being a marker of accelerated atherosclerosis or inflammation.
研究血清唾液酸水平与未诊断出心血管疾病的男性和女性患冠心病（CHD）及中风风险之间的关系。
采用1981年至1998年期间的一项前瞻性病例队列研究，涉及151例冠心病病例、87例中风病例以及一个由340人组成的随机子队列。通过酶法从冷冻血清中测定唾液酸水平。在对年龄、血压、体重指数、胆固醇、甘油三酯、糖尿病和吸烟进行调整后，使用Cox比例风险回归来估计唾液酸三分位数以及连续唾液酸水平与冠心病和中风的相对风险。
总体而言，唾液酸水平每升高25mg/dl，经多变量调整后的冠心病相对风险为1.22（95%CI：1.02 - 1.45），女性为1.40（95%CI：1.11 - 1.76），男性为1.06（95%CI：0.82 - 1.37）。中风的总体相对风险为1.13（95%CI：0.87 - 1.46），冠心病和中风合并的相对风险为1.17（95%CI：0.99 - 1.37）。
血清唾液酸可能是目前临床上无心血管疾病的成年人（尤其是女性）冠心病事件的长期预测指标。需要进一步研究以确定这种关联是否可以通过唾液酸作为动脉粥样硬化加速或炎症的标志物来解释。
