卵巢癌患者血清糖蛋白水平升高。
Serum Levels of Glycoproteins are Elevated in Patients with Ovarian Cancer.
作者信息
Thakkar Vikram, Patel Purvi, Prajapati Neelam, Kaur Ranjit, Nandave Mukesh
机构信息
Pharmacy Department, M. S. University of Baroda, Vadodara, India.
Department of Obstetrics and Gynecology, S.S.G. Hospital, Baroda, India.
出版信息
Indian J Clin Biochem. 2014 Jul;29(3):345-50. doi: 10.1007/s12291-013-0380-6. Epub 2013 Sep 8.
Identification of reliable biomarkers for detection and staging of cancer and monitoring the outcome of anticancer therapy has been considered to be of high importance. We aimed to estimate the levels of serum glycoproteins, protein bound-hexose, protein bound hexosamine, protein bound fucose, protein bound sialic acid and protein bound carbohydrate in 32 ovarian cancer patients and compared them with the levels that found in 25 normal subjects. As compared to the normal subjects, all the four fractions of glycoproteins level were significantly elevated in ovarian cancer patients (p < 0.05). Chemotherapy in these patients significantly decreased the levels of serum glycoproteins (p < 0.05). Thus, high levels of serum glycoproteins in ovarian cancer patients could be due to abnormal protein glycosylation indicating malignant transformation of the cells.
鉴定用于癌症检测、分期及监测抗癌治疗效果的可靠生物标志物一直被认为至关重要。我们旨在估算32例卵巢癌患者血清糖蛋白、蛋白结合己糖、蛋白结合氨基己糖、蛋白结合岩藻糖、蛋白结合唾液酸和蛋白结合碳水化合物的水平，并将其与25名正常受试者的水平进行比较。与正常受试者相比，卵巢癌患者糖蛋白水平的所有四个组分均显著升高（p < 0.05）。这些患者接受化疗后，血清糖蛋白水平显著降低（p < 0.05）。因此，卵巢癌患者血清糖蛋白水平升高可能是由于异常的蛋白质糖基化，这表明细胞发生了恶性转化。
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