恶性疟原虫和间日疟原虫肿瘤坏死因子诱导外抗原的血清学关系。
Serological relationship of tumor necrosis factor-inducing exoantigens of Plasmodium falciparum and Plasmodium vivax.
作者信息
Bate C A, Taverne J, Karunaweera N D, Mendis K N, Kwiatkowski D, Playfair J H
机构信息
Department of Immunology, University College and Middlesex School of Medicine, London, United Kingdom.
出版信息
Infect Immun. 1992 Mar;60(3):1241-3. doi: 10.1128/iai.60.3.1241-1243.1992.
Abstract
Exoantigens of Plasmodium vivax-parasitized erythrocytes stimulated macrophages to secrete tumor necrosis factor, and antisera raised against the exoantigens inhibited this secretion. The antisera also inhibited the activity of Plasmodium falciparum and Plasmodium yoelii exoantigens, and conversely, antisera against the latter cross-reacted with the exoantigens of P. vivax.
摘要
间日疟原虫寄生的红细胞外抗原刺激巨噬细胞分泌肿瘤坏死因子，针对该外抗原产生的抗血清可抑制这种分泌。该抗血清还可抑制恶性疟原虫和约氏疟原虫外抗原的活性，反之，针对后两者的抗血清可与间日疟原虫的外抗原发生交叉反应。
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