Siqueira Ionara Rodrigues, Cimarosti Helena, Fochesatto Cíntia, Salbego Christianne, Netto Carlos Alexandre
Programa de Pós Graduação em Ciências Biológicas-Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Brain Res. 2004 Oct 29;1025(1-2):226-30. doi: 10.1016/j.brainres.2004.08.005.
Aging is an important risk factor for stroke. We evaluated the effects of aging on cell susceptibility to oxygen and glucose deprivation (OGD) in slices of the hippocampus from Wistar rats aged 2, 11 and 24 months. Lactate dehydrogenase (LDH) released to the incubation media and free radical content were markedly increased in the 24-month group submitted to OGD. These results confirm that hippocampal tissue from old animals is more susceptible to ischemia-reoxygenation injury.
衰老为中风的重要风险因素。我们评估了衰老对2月龄、11月龄和24月龄Wistar大鼠海马切片中细胞对氧糖剥夺（OGD）的易感性的影响。在接受OGD处理的24月龄组中，释放到孵育培养基中的乳酸脱氢酶（LDH）和自由基含量显著增加。这些结果证实，老年动物的海马组织对缺血再灌注损伤更敏感。
