Sodeck G, Domanovits H, Khanakah G, Schillinger M, Thalmann M, Bayegan K, Schoder M, Grabenwoeger M, Hoelzenbein T, Boehmig G, Laggner A N, Stanek G
Department of Emergency Medicine, Medical University of Vienna, General Hospital Vienna, Austria, Europe.
Eur J Vasc Endovasc Surg. 2004 Nov;28(5):547-52. doi: 10.1016/j.ejvs.2004.07.019.
The role of Chlamydia pneumoniae in the pathogenesis of aortic aneurysm is controversial. We investigated the presence of C. pneumoniae in tissue samples excised from patients and controls.
Aortic wall specimens were obtained from 17 patients with acute Stanford type A aortic dissection, 25 patients with thoracic aortic aneurysms (TAA) and 23 patients with abdominal aortic aneurysms (AAA). Eighty-three tissue samples of 73 control patients free of aortic disease were obtained either at surgery or autopsy. The presence of Chlamydia subspecies DNA (sequences specific for all known Chlamydiaceae) and DNA of C. pneumoniae, C. trachomatis and C. psittaci were assessed by a validated highly sensitive and specific real time polymerase chain reaction (PCR) analysis. Atherosclerotic risk factors were assessed in all patients.
We failed to detect C. pneumoniae and C. psittaci-DNA in any of the 148 vessel specimens. C. trachomatis-DNA was detected in 1/65 patients and in none of 83 controls (P=0.43). Chlamydia subspecies DNA was found in samples of eight cases and in one control (P=0.01), however, no significant differences were found between the subgroups aortic dissection (P=0.09), TAA (P=0.99) and AAA (P=0.15) and respective controls.
C. pneumoniae does not play a clinically relevant role in acute and chronic aortic disease. The impact of other organisms of the family Chlamydiaceae needs further evaluation.
肺炎衣原体在主动脉瘤发病机制中的作用存在争议。我们调查了从患者和对照者切除的组织样本中肺炎衣原体的存在情况。
从17例急性Stanford A型主动脉夹层患者、25例胸主动脉瘤（TAA）患者和23例腹主动脉瘤（AAA）患者获取主动脉壁标本。73例无主动脉疾病的对照患者的83个组织样本通过手术或尸检获得。通过经过验证的高灵敏度和特异性实时聚合酶链反应（PCR）分析评估衣原体亚种DNA（所有已知衣原体科的特异性序列）以及肺炎衣原体、沙眼衣原体和鹦鹉热衣原体的DNA。对所有患者评估动脉粥样硬化危险因素。
在148个血管标本中均未检测到肺炎衣原体和鹦鹉热衣原体DNA。在65例患者中的1例检测到沙眼衣原体DNA，而83例对照中均未检测到（P = 0.43）。在8例患者样本和1例对照中发现了衣原体亚种DNA（P = 0.01），然而，在主动脉夹层亚组（P = 0.09）、胸主动脉瘤亚组（P = 0.99）和腹主动脉瘤亚组（P = 0.15）与各自的对照之间未发现显著差异。
肺炎衣原体在急性和慢性主动脉疾病中不发挥临床相关作用。衣原体科其他生物体的影响需要进一步评估。
