Yu H, Rohan T E, Cook M G, Howe G R, Miller A B
Epidemiology Unit, National Cancer Institute of Canada, University of Toronto, Ontario, Canada.
Am J Epidemiol. 1992 Feb 1;135(3):247-58. doi: 10.1093/oxfordjournals.aje.a116278.
Risk factors for fibroadenoma were examined in a case-control study involving 117 fibroadenoma cases ascertained by a major private pathology laboratory in Adelaide, Australia, between January 1983 and October 1985. For each case a population control was randomly selected from the electoral roll in Adelaide and matched to the corresponding case by sex, age, and socioeconomic grading of area of residence. Another 189 women whose first biopsy for benign breast disease was examined in the same laboratory during the same time period as those of the cases, but did not show evidence of epithelial proliferation, were also included in the study as a biopsy control group. Risk of fibroadenoma was associated inversely with the Quetelet index, but there was no evidence of an association with age at menarche or menopausal status. The risk of fibroadenoma decreased with an increasing number of full-term pregnancies and was increased in association with use of oral contraceptives at an early age (under 20 years); however, these two associations were observed only when cases were compared with the population controls. Alcohol consumption and dietary fat intake were found not to be associated with altered risk of fibroadenoma, while in multivariate analyses, duration of cigarette smoking and daily vitamin C intake were both shown to have inverse associations with risk of fibroadenoma. Although fibroadenoma does share some risk factors with breast cancer, there is insufficient evidence to suggest that it represents a precursor state.
在一项病例对照研究中，对纤维腺瘤的危险因素进行了调查。该研究涉及1983年1月至1985年10月期间由澳大利亚阿德莱德一家大型私立病理实验室确诊的117例纤维腺瘤病例。对于每例病例，从阿德莱德的选民名单中随机选取一名人群对照，并根据性别、年龄和居住地区的社会经济等级与相应病例进行匹配。另外，在同一时期，与病例在同一实验室接受首次良性乳腺疾病活检但未显示上皮增生迹象的189名女性也作为活检对照组纳入研究。纤维腺瘤的风险与克托莱指数呈负相关，但没有证据表明与初潮年龄或绝经状态有关。纤维腺瘤的风险随着足月妊娠次数的增加而降低，且与早年（20岁以下）使用口服避孕药有关；然而，这两种关联仅在将病例与人群对照进行比较时才观察到。发现饮酒和饮食脂肪摄入量与纤维腺瘤风险改变无关，而在多变量分析中，吸烟持续时间和每日维生素C摄入量均与纤维腺瘤风险呈负相关。尽管纤维腺瘤确实与乳腺癌有一些共同的危险因素，但没有足够的证据表明它代表一种前驱状态。
