LiVolsi V A, Stadel B V, Kelsey J L, Holford T R
Cancer. 1979 Nov;44(5):1778-81. doi: 10.1002/1097-0142(197911)44:5<1778::aid-cncr2820440535>3.0.co;2-y.
We have reviewed histologically a series of 120 fibroadenomas which formed part of the case material from a previous case-control epidemiological investigation of the relationship between oral contraceptive use and breast disease. We evaluated the epithelial component of the fibroadenoma for degree of cytologic atypia. This study indicates that the reduced risk for fibroadenoma among long-term users of oral contraceptives does not vary according to the degree of epithelial atypia present. This is in contrast to our previously reported findings for fibrocystic disease, in which the decreased frequency of occurrence of the disease in long-term users of oral contraceptives was found only for cases with no minimal epithelial atypia.
我们对120例纤维腺瘤进行了组织学检查，这些纤维腺瘤是之前一项关于口服避孕药使用与乳腺疾病关系的病例对照流行病学调查病例材料的一部分。我们评估了纤维腺瘤上皮成分的细胞异型程度。本研究表明，长期口服避孕药使用者患纤维腺瘤风险降低的情况，并不因存在的上皮异型程度不同而有所差异。这与我们之前报道的纤维囊性疾病的研究结果相反，在纤维囊性疾病中，仅在无最小限度上皮异型的病例中发现长期口服避孕药使用者该疾病的发生频率降低。
