女性饮酒与8年体重增加：一项前瞻性研究。

Alcohol intake and 8-year weight gain in women: a prospective study.

作者信息

Wannamethee S Goya, Field Alison E, Colditz Graham A, Rimm Eric B

机构信息

Department of Primary Care and Population Science, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, United Kingdom.

出版信息

Obes Res. 2004 Sep;12(9):1386-96. doi: 10.1038/oby.2004.175.

DOI:10.1038/oby.2004.175

PMID:15483203

Abstract

OBJECTIVE

To examine prospectively the relationship between alcohol and 8-year weight gain in women.

RESEARCH METHODS AND PROCEDURES

A prospective study of 49,324 women 27 to 44 years old who did not have a history of cardiovascular disease, cancer, or diabetes, who were not pregnant during the study period, and who reported weights in 1991 and 1999.

RESULTS

In cross-sectional analyses, there was a significant inverse relationship between alcohol and BMI even after adjustment for dietary factors and a wide range of confounders. In multivariate prospective analyses, a nonlinear relationship was seen between alcohol and weight gain (>or=5 kg) in all women. Compared with nondrinkers, the adjusted relative odds [95% confidence interval (CI)] of weight gain according to grams per day were 0.94 (0.89, 0.99) for those consuming 0.1 to 4.9 g/d, 0.92 (0.85,0.99) for 5 to 14.9 g/d, 0.86 (0.76, 0.78) for 15 to 29.9 g/d, and 1.07 (0.89,1.28) for those consuming 30+ g/d (p < 0.0001 for quadratic trend). Women who continued to drink heavily and those who became heavy drinkers showed similar increased odds of weight gain. The increased odds of weight gain associated with heavy drinking (30+ g/d) were most marked in the younger women (<35 years) (odds ratio 1.64; 5% CI 1.03 to 2.61). In African-American women, light drinking was associated with increased odds of weight gain compared with nondrinkers (odds ratio = 2.43; 95% CI 1.22 to 4.82).

DISCUSSION

Our data suggest that light to moderate drinking (up to 30 g/d) is not associated with weight gain in women except possibly in African-American women. Heavier drinking may promote weight gain in women.

摘要

目的

前瞻性研究女性饮酒与8年体重增加之间的关系。

研究方法与步骤

对49324名年龄在27至44岁之间、无心血管疾病、癌症或糖尿病病史、在研究期间未怀孕且报告了1991年和1999年体重的女性进行前瞻性研究。

结果

在横断面分析中，即使在调整饮食因素和一系列混杂因素后，饮酒与体重指数之间仍存在显著的负相关关系。在多变量前瞻性分析中，所有女性的饮酒量与体重增加（≥5千克）之间呈现非线性关系。与不饮酒者相比，根据每日克数计算，体重增加的调整后相对比值[95%置信区间（CI）]在每天摄入0.1至4.9克酒精的人群中为0.94（0.89，0.99），5至14.9克/天为0.92（0.85，0.99），15至29.9克/天为0.86（0.76，0.78），每天摄入30克及以上酒精的人群为1.07（0.89，1.28）（二次趋势p<0.0001）。持续大量饮酒的女性和开始大量饮酒的女性体重增加的几率相似。与大量饮酒（≥30克/天）相关的体重增加几率在年轻女性（<35岁）中最为明显（比值比1.64；5%CI 1.03至2.61）。在非裔美国女性中，与不饮酒者相比，轻度饮酒与体重增加几率增加相关（比值比=2.43；95%CI 1.22至4.82）。