Tiemersma Edine W, Bronzwaer Stef L A M, Lyytikäinen Outi, Degener John E, Schrijnemakers Paul, Bruinsma Nienke, Monen Jos, Witte Wolfgang, Grundman Hajo
National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Emerg Infect Dis. 2004 Sep;10(9):1627-34. doi: 10.3201/eid1009.040069.
We explored the variation in proportions of methicillin-resistant Staphylococcus aureus (MRSA) between and within countries participating in the European Antimicrobial Resistance Surveillance System and temporal trends in its occurrence. This system collects routine antimicrobial susceptibility tests for S. aureus. We examined data collected from January 1999 through December 2002 (50,759 isolates from 495 hospitals in 26 countries). MRSA prevalence varied almost 100-fold, from <1% in northern Europe to >40% in southern and western Europe. MRSA proportions significantly increased in Belgium, Germany, Ireland, the Netherlands, and the United Kingdom, and decreased in Slovenia. Within countries, MRSA proportions varied between hospitals with highest variance in countries with a prevalence of 5% to 20%. The observed trends should stimulate initiatives to control MRSA at national, regional, and hospital levels. The large differences between hospitals indicate that efforts may be most effective at regional and hospital levels.
我们探究了参与欧洲抗菌药物耐药性监测系统的国家之间及国家内部耐甲氧西林金黄色葡萄球菌（MRSA）比例的差异，以及其出现的时间趋势。该系统收集金黄色葡萄球菌的常规抗菌药物敏感性试验数据。我们检查了1999年1月至2002年12月期间收集的数据（来自26个国家495家医院的50,759株分离菌）。MRSA患病率相差近100倍，从北欧的<1%到南欧和西欧的>40%。比利时、德国、爱尔兰、荷兰和英国的MRSA比例显著增加，而斯洛文尼亚的MRSA比例下降。在各国国内，MRSA比例在患病率为5%至20%的国家中，医院之间差异最大。观察到的趋势应促使各国在国家、区域和医院层面采取控制MRSA的举措。医院之间的巨大差异表明，在区域和医院层面开展工作可能最有成效。
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