Lorenz I
Clinic for Ruminants, University of Munich, Sonnenstrasse 16, 85764 Oberschleissheim, Germany.
Vet J. 2004 Nov;168(3):323-7. doi: 10.1016/j.tvjl.2003.10.021.
Correlations between the degree of acidosis and clinical signs (changes in posture, behaviour, intensity of suckling reflex) in neonatal diarrhoeic calves have been described in various studies. However, base excess values varied widely in calves exhibiting similar clinical symptoms. The objective of this study was to elucidate whether the clinical picture of acidotic calves with neonatal diarrhoea is influenced more by D-lactate concentration than by degree of acidosis. Eighty calves up to three weeks old that were admitted to the II Medical Animal Clinic with acute diarrhoea and base excess values between -10 and -25 mmol/L were included in the prospective study. Posture, behaviour, suckling and palpebral reflexes, and position of the eyeballs were scored during the initial examination. Base excess and serum D-lactate and urea concentrations were determined in venous blood. In order to quantify the influences of base excess and d-lactate on the clinical parameters, groups of different clinical categories were compared. The results show that variations in behaviour, and in posture can be better explained by elevations of serum D-lactate concentrations than by decreases in base excess. Disturbances of the palpebral reflex appear to be almost completely caused by high levels of D-lactate.
多项研究描述了新生腹泻犊牛酸中毒程度与临床体征（姿势变化、行为、吸吮反射强度）之间的相关性。然而，表现出相似临床症状的犊牛碱剩余值差异很大。本研究的目的是阐明新生腹泻酸中毒犊牛的临床症状受D - 乳酸浓度的影响是否大于酸中毒程度。80头3周龄以内因急性腹泻入住第二医学动物诊所且碱剩余值在 - 10至 - 25 mmol/L之间的犊牛被纳入该前瞻性研究。在初次检查时对姿势、行为、吸吮和眼睑反射以及眼球位置进行评分。测定静脉血中的碱剩余、血清D - 乳酸和尿素浓度。为了量化碱剩余和D - 乳酸对临床参数的影响，对不同临床类别的组进行了比较。结果表明，血清D - 乳酸浓度升高比碱剩余降低能更好地解释行为和姿势的变化。眼睑反射障碍似乎几乎完全由高水平的D - 乳酸引起。
