Vianna J L, Haga H J, Tripathi P, Cervera R, Khamashta M A, Hughes G R
Lupus Arthritis Research Unit, Rayne Institute, St Thomas's Hospital, London, United Kingdom.
Ann Rheum Dis. 1992 Feb;51(2):160-1. doi: 10.1136/ard.51.2.160.
The antiphospholipid syndrome was initially described in 1986. To reassess the validity of antiphospholipid antibodies in systemic lupus erythematosus (SLE), 95 patients with SLE were studied. Their antiphospholipid antibody profile was analysed and correlated with clinical findings such as thrombosis, abortions, or thrombocytopenia. A low prevalence of these antibodies was found (13 patients; 14%) with a high specificity for thrombosis (92%) and abortions (92%). The importance of anticardiolipin antibodies as a risk factor for thrombosis or abortions, or both, in patients with SLE is reaffirmed by this work.
抗磷脂综合征最初于1986年被描述。为重新评估抗磷脂抗体在系统性红斑狼疮（SLE）中的有效性，对95例SLE患者进行了研究。分析了他们的抗磷脂抗体谱，并将其与血栓形成、流产或血小板减少等临床发现相关联。发现这些抗体的患病率较低（13例患者；14%），对血栓形成（92%）和流产（92%）具有高度特异性。这项研究再次证实了抗心磷脂抗体作为SLE患者血栓形成或流产或两者的危险因素的重要性。
