Barocelli E, Calcina F, Chiavarini M, Impicciatore M, Bruni R, Bianchi A, Ballabeni V
Dipartimento di Scienze Farmacologiche, Biologiche e Chimiche Applicate, Università di Parma, Parco Area delle Scienze 27/a, 43100 Parma, Italy.
Life Sci. 2004 Nov 26;76(2):213-23. doi: 10.1016/j.lfs.2004.08.008.
In this study the antinociceptive and the gastroprotective effects of orally administered or inhaled Lavandula hybrida Reverchon "Grosso" essential oil, and its principal constituents linalool and linalyl acetate were evaluated in rodents. Either when orally administered (100 mg/kg) or inhaled for 60 min lavender essential oil significantly reduced the acetic acid-writhing response in a naloxone-sensitive manner. In the hot plate test, analgesic activity observed after oil inhalation was inhibited by naloxone, atropine, mecamylamine pretreatment suggesting the involvement of opioidergic as well as cholinergic pathways. Regardless of the administration route and the experimental model used both linalool and linalyl acetate did not produce significant analgesic response. Oral or inhalatory treatment with analgesic doses of essential oil did not affect mice spontaneous locomotor activity. Concerning the gastric effects, lavender oil, linalool and linalyl acetate oral administration protected against acute ethanol-induced gastric ulcers but did not prevent indomethacin-induced lesions indicating no interference with arachidonic acid metabolic cascade. In conclusion, besides this gastroprotection, lavender oil reveals an interesting analgesic activity mainly relevant after inhalation, at doses devoid of sedative side effect, suggesting the interest for potential application of this oil in aromatherapy.
在本研究中，评估了经口给药或吸入的杂交薰衣草“格罗索”精油及其主要成分芳樟醇和乙酸芳樟酯在啮齿动物中的抗伤害感受和胃保护作用。无论是经口给药（100mg/kg）还是吸入60分钟，薰衣草精油均以对纳洛酮敏感的方式显著降低了醋酸扭体反应。在热板试验中，吸入精油后观察到的镇痛活性被纳洛酮、阿托品、美加明预处理所抑制，提示阿片能途径以及胆碱能途径均参与其中。无论给药途径和所使用的实验模型如何，芳樟醇和乙酸芳樟酯均未产生显著的镇痛反应。用镇痛剂量的精油进行口服或吸入治疗均不影响小鼠的自发运动活性。关于胃效应，薰衣草油、芳樟醇和乙酸芳樟酯经口给药可预防急性乙醇诱导的胃溃疡，但不能预防吲哚美辛诱导的损伤，表明对花生四烯酸代谢级联没有干扰。总之，除了这种胃保护作用外，薰衣草油还显示出有趣的镇痛活性，主要在吸入后出现，且剂量无镇静副作用，这表明该精油在芳香疗法中的潜在应用具有价值。
