Will B H, Suttie J W
Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison 53706.
J Nutr. 1992 Apr;122(4):953-8. doi: 10.1093/jn/122.4.953.
The hepatic turnover of phylloquinone and menaquinone-9 (MK-9) and their relative efficacy in satisfying the dietary requirement for vitamin K were compared in male rats. Rats fed 1.1 mumol phylloquinone/kg diet had higher initial liver and serum vitamin K concentrations than rats fed an equimolar amount of MK-9. The initial rate of hepatic turnover of phylloquinone was two to three times as rapid as that of MK-9. After about 48 h of vitamin K restriction there were no significant differences in hepatic vitamin K concentration of rats fed phylloquinone or MK-9. Phylloquinone was much more effective than MK-9 in maintaining normal vitamin K status at low dietary concentrations (0.2 mumol/kg diet), whereas at high dietary concentrations (5.6 mumol/kg diet) they were equally effective.
在雄性大鼠中比较了叶绿醌和甲基萘醌-9（MK-9）的肝脏周转率及其在满足维生素K膳食需求方面的相对功效。喂食1.1 μmol叶绿醌/千克日粮的大鼠，其肝脏和血清维生素K的初始浓度高于喂食等摩尔量MK-9的大鼠。叶绿醌的肝脏周转率初始速率是MK-9的两到三倍。在维生素K限制约48小时后，喂食叶绿醌或MK-9的大鼠肝脏维生素K浓度没有显著差异。在低膳食浓度（0.2 μmol/千克日粮）下，叶绿醌在维持正常维生素K状态方面比MK-9有效得多，而在高膳食浓度（5.6 μmol/千克日粮）下，它们同样有效。
