• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
HDR-192Ir intraluminal brachytherapy in treatment of malignant obstructive jaundice.高剂量率192铱腔内近距离放射治疗恶性梗阻性黄疸
World J Gastroenterol. 2004 Dec 1;10(23):3506-10. doi: 10.3748/wjg.v10.i23.3506.
2
Clinical benefit of radiation therapy and metallic stenting for unresectable hilar cholangiocarcinoma.放疗联合金属支架置入治疗不可切除肝门部胆管癌的临床获益。
World J Gastroenterol. 2012 May 21;18(19):2364-70. doi: 10.3748/wjg.v18.i19.2364.
3
A Systematic Review and Meta-analysis of Intraluminal Brachytherapy Versus Stent Alone in the Treatment of Malignant Obstructive Jaundice.腔内近距离放射治疗与单纯支架置入治疗恶性梗阻性黄疸的系统评价和荟萃分析
Cardiovasc Intervent Radiol. 2018 Feb;41(2):206-217. doi: 10.1007/s00270-017-1827-6. Epub 2017 Oct 26.
4
The use of ¹²⁵I seed strands for intraluminal brachytherapy of malignant obstructive jaundice.¹²⁵I 种子丝在恶性梗阻性黄疸腔内近距离放疗中的应用。
Cancer Biother Radiopharm. 2012 Jun;27(5):317-23. doi: 10.1089/cbr.2011.0999. Epub 2011 Sep 8.
5
Intraluminal brachytherapy without stenting in intrahepatic papillary cholangiocarcinoma: a case report.肝内乳头状胆管癌无支架置入的腔内近距离放射治疗：病例报告
Dig Liver Dis. 2005 Aug;37(8):615-8. doi: 10.1016/j.dld.2004.07.022.
6
Malignant biliary duct obstruction: long-term experience with Gianturco stents and combined-modality radiation therapy.恶性胆管梗阻：关于 Gianturco 支架及综合放射治疗的长期经验
Radiology. 1996 Sep;200(3):717-24. doi: 10.1148/radiology.200.3.8756921.
7
Intraluminal brachytherapy with metallic stenting in the palliative treatment of malignant obstruction of the bile duct.腔内近距离放射治疗联合金属支架置入术用于胆管恶性梗阻的姑息治疗
Radiat Med. 2005 May;23(3):200-7.
8
A Phase I study of high-dose-rate intraluminal brachytherapy as palliative treatment in extrahepatic biliary tract cancer.一项关于高剂量率腔内近距离放射治疗作为肝外胆管癌姑息治疗的I期研究。
Brachytherapy. 2015 May-Jun;14(3):401-4. doi: 10.1016/j.brachy.2014.12.002. Epub 2015 Jan 13.
9
Relief of jaundice by external beam radiotherapy and intraluminal brachytherapy in patients with extrahepatic cholangiocarcinoma: results without stenting.肝外胆管癌患者接受体外照射放疗和腔内近距离放疗后黄疸缓解情况：未置入支架的结果
Hepatogastroenterology. 2004 Jul-Aug;51(58):954-7.
10
Brachytherapy and percutaneous stenting in the treatment of cholangiocarcinoma: a prospective randomised study.近距离放射治疗与经皮支架置入术治疗胆管癌：一项前瞻性随机研究。
Eur J Radiol. 2007 May;62(2):175-9. doi: 10.1016/j.ejrad.2007.01.037. Epub 2007 Mar 6.

引用本文的文献

1
Biliary metallic stent combined with radioactive 125I seeds strands for malignant hilar obstruction.胆道金属支架联合放射性125I粒子链治疗恶性肝门部梗阻
BMC Cancer. 2025 Feb 10;25(1):229. doi: 10.1186/s12885-025-13627-w.
2
Biliary drainage combined with simultaneous I seed strand brachytherapy for the treatment of hilar cholangiocarcinoma.胆管引流联合 I 粒子链近距离放疗治疗肝门部胆管癌。
BMC Cancer. 2023 May 9;23(1):418. doi: 10.1186/s12885-023-10868-5.
3
Outcomes of two types of iodine-125 seed delivery with metal stents in treating malignant biliary obstruction: a systematic review and meta-analysis.两种类型的碘 125 种子输送联合金属支架治疗恶性胆道梗阻的疗效：系统评价和荟萃分析。
Diagn Interv Radiol. 2023 May 31;29(3):509-519. doi: 10.5152/dir.2022.211277. Epub 2023 Feb 21.
4
Role of intraluminal brachytherapy in palliation of biliary obstruction in cholangiocarcinoma: A brief review.腔内近距离放射治疗在胆管癌胆道梗阻姑息治疗中的作用：简要综述。
World J Gastrointest Endosc. 2022 Mar 16;14(3):106-112. doi: 10.4253/wjge.v14.i3.106.
5
Endoscopic Management of Pancreatobiliary Malignancies.内镜处理胰腺胆道恶性肿瘤。
Dig Dis Sci. 2022 May;67(5):1635-1648. doi: 10.1007/s10620-022-07394-y. Epub 2022 Feb 16.
6
A Comparative Study of Self-Expandable Metallic Stent Combined with Double I Seeds Strands or Single I Seeds Strand in the Treatment of Advanced Perihilar Cholangiocarcinoma with Malignant Obstructive Jaundice.自膨式金属支架联合双碘粒子链或单碘粒子链治疗晚期肝门部胆管癌伴恶性梗阻性黄疸的对比研究
Onco Targets Ther. 2021 Jul 6;14:4077-4086. doi: 10.2147/OTT.S312162. eCollection 2021.
7
Extrahepatic cholangiocarcinoma: Current status of endoscopic approach and additional therapies.肝外胆管癌：内镜治疗方法及其他治疗的现状
World J Hepatol. 2021 Feb 27;13(2):166-186. doi: 10.4254/wjh.v13.i2.166.
8
The Evolving Role of Radiation Therapy in the Treatment of Biliary Tract Cancer.放射治疗在胆管癌治疗中不断演变的作用
Front Oncol. 2020 Dec 14;10:604387. doi: 10.3389/fonc.2020.604387. eCollection 2020.
9
Monitoring outcomes in intrahepatic cholangiocarcinoma patients following hepatic resection.肝切除术后肝内胆管癌患者的预后监测
Hepat Oncol. 2016 Oct;3(4):223-239. doi: 10.2217/hep-2016-0009. Epub 2017 Jan 20.
10
Current status of brachytherapy in cancer treatment - short overview.近距离放射疗法在癌症治疗中的现状——简要概述。
J Contemp Brachytherapy. 2017 Dec;9(6):581-589. doi: 10.5114/jcb.2017.72607. Epub 2017 Dec 30.

本文引用的文献

1
Percutaneous placement of biliary metallic stents in patients with malignant hilar obstruction: unilobar versus bilobar drainage.恶性肝门部梗阻患者经皮胆道金属支架置入术：单叶引流与双叶引流
J Vasc Interv Radiol. 2003 Nov;14(11):1409-16. doi: 10.1097/01.rvi.0000096762.74047.a6.
2
Percutaneous radiofrequency ablation of pulmonary malignancies: combined treatment with brachytherapy.经皮射频消融治疗肺部恶性肿瘤：与近距离放射治疗联合应用
AJR Am J Roentgenol. 2003 Sep;181(3):711-5. doi: 10.2214/ajr.181.3.1810711.
3
Selective MRCP and CT-targeted drainage of malignant hilar biliary obstruction with self-expanding metallic stents.使用自膨式金属支架对恶性肝门部胆管梗阻进行选择性磁共振胰胆管造影（MRCP）和CT引导下引流
Gastrointest Endosc. 2003 Jul;58(1):41-9. doi: 10.1067/mge.2003.292.
4
Multicenter randomized trial of the spiral Z-stent compared with the Wallstent for malignant biliary obstruction.
Gastrointest Endosc. 2003 Jun;57(7):830-6. doi: 10.1016/s0016-5107(03)70016-9.
5
Percutaneous placement of metallic stents in malignant biliary obstruction: one-stage or two-stage procedure? Pre-dilate or not?经皮金属支架置入术治疗恶性胆管梗阻：一期手术还是二期手术？是否预扩张？
Cardiovasc Intervent Radiol. 2003 Jan-Feb;26(1):40-5. doi: 10.1007/s00270-002-2647-9. Epub 2002 Dec 20.
6
Preoperative evaluation of gallbladder carcinoma: efficacy of combined use of MR imaging, MR cholangiography, and contrast-enhanced dual-phase three-dimensional MR angiography.
J Magn Reson Imaging. 2002 Dec;16(6):676-84. doi: 10.1002/jmri.10212.
7
Percutaneous self-expanding metal stents versus endoscopic polyethylene endoprostheses for treating malignant biliary obstruction: randomized clinical trial.经皮自膨式金属支架与内镜下聚乙烯内支架治疗恶性胆道梗阻的随机临床试验
Radiology. 2002 Oct;225(1):27-34. doi: 10.1148/radiol.2243011517.
8
Effectiveness of the Ultraflex Diamond stent for the palliation of malignant biliary obstruction.Ultraflex钻石支架用于缓解恶性胆道梗阻的疗效
Endoscopy. 2002 Oct;34(10):793-6. doi: 10.1055/s-2002-34269.
9
Intraluminal high dose rate brachytherapy in the treatment of bile duct and gallbladder carcinomas.腔内高剂量率近距离放射疗法治疗胆管癌和胆囊癌。
Hepatogastroenterology. 2002 Jul-Aug;49(46):916-7.
10
Transduodenal intraluminal high dose rate brachytherapy in the treatment of carcinomas of the subhepatic region.
Hepatogastroenterology. 2002 Jul-Aug;49(46):1045-7.

高剂量率192铱腔内近距离放射治疗恶性梗阻性黄疸

HDR-192Ir intraluminal brachytherapy in treatment of malignant obstructive jaundice.

作者信息

Chen Yi, Wang Xiao-Lin, Yan Zhi-Ping, Cheng Jie-Min, Wang Jian-Hua, Gong Gao-Quan, Qian Sheng, Luo Jian-Jun, Liu Qing-Xin

机构信息

Department of Radiology, Affiliated Zhongshan Hospital, Medical Center of Fudan University, Shanghai 200032, China.

出版信息

World J Gastroenterol. 2004 Dec 1;10(23):3506-10. doi: 10.3748/wjg.v10.i23.3506.

DOI:10.3748/wjg.v10.i23.3506
PMID:15526374
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4576236/
Abstract

AIM

To determine the feasibility and safety of intraluminal brachytherapy in treatment of malignant obstructive jaundice (MOJ) and to evaluate the clinical effect of intraluminal brachytherapy on stent patency and patient survival.

METHODS

Thirty-four patients with MOJ were included in this study. Having biliary stent placed, all patients were classified into intraluminal brachytherapy group (group A, n = 14) and control group (group B, n = 20) according to their own choice. Intraluminal brachytherapy regimen included: HDR-192Ir was used in the therapy, fractional doses of 4-7 Gy were given every 3-6 d for 3-4 times, and standard points were established at 0.5-1.0 cm. Some patients of both groups received transcatheter arterial chemoembolization (TACE) after stent placement.

RESULTS

In group A, the success rate of intraluminal brachytherapy was 98.0%, RTOG grade 1 acute radiation morbidity occurred in 3 patients, RTOG/EORTC grade 1 late radiation morbidity occurred in 1 patient. Mean stent patency of group A (12.6 mo) was significantly longer than that of group B (8.3 mo) (P<0.05). There was no significant difference in the mean survival (9.4 mo vs 6.0 mo) between the two groups.

CONCLUSION

HDR-192Ir intraluminal brachytherapy is a safe palliative therapy in treating MOJ, and it may prolong stent patency and has the potentiality of extending survival of patients with MOJ.

摘要

目的

探讨腔内近距离放射治疗恶性梗阻性黄疸（MOJ）的可行性和安全性，并评估腔内近距离放射治疗对支架通畅性和患者生存的临床效果。

方法

本研究纳入34例MOJ患者。所有患者均放置胆管支架，根据自身选择分为腔内近距离放射治疗组（A组，n = 14）和对照组（B组，n = 20）。腔内近距离放射治疗方案包括：采用高剂量率192铱进行治疗，每3 - 6天给予4 - 7 Gy的分次剂量，共3 - 4次，在0.5 - 1.0 cm处设定标准点。两组部分患者在支架置入后接受经动脉化疗栓塞术（TACE）。

结果

A组腔内近距离放射治疗成功率为98.0%，3例患者发生RTOG 1级急性放射性损伤，1例患者发生RTOG/EORTC 1级晚期放射性损伤。A组支架平均通畅时间（12.6个月）显著长于B组（8.3个月）（P<0.05）。两组平均生存期无显著差异（9.4个月对6.个月）。

结论

高剂量率192铱腔内近距离放射治疗是治疗MOJ的一种安全的姑息治疗方法，可能延长支架通畅时间，并有延长MOJ患者生存期的潜力。