Martiny K
Psychiatric Research Unit, Frederiksborg General Hospital, Hilleroed, Denmark.
Acta Psychiatr Scand Suppl. 2004(425):7-28. doi: 10.1111/j.1600-0447.2004.00460_2.x.
Bright light treatment is an established treatment for Seasonal Affective Disorder, but in non-seasonal depression research results have been contrasting.
This study was designed as a 5-week controlled, double-blind, parallel trial in out-patients with a diagnosis (DSM-IV) of non-seasonal major depression, randomized to either active treatment (white light, 10 000 lux, 1 h daily) or placebo treatment (red light, 50 lux, 30 min daily) and concomitant treatment with sertraline in both groups.
One hundred and two patients were included in the study. Analyses showed that on all used scales the reduction in depression scores was larger in the bright light group than in the dim light group, and this reached statistical significance on all observer rating scales and on the SCL-90R self-assessment scale. The HAM-D6 was the most sensitive scale to measure improvement at endpoint.
The study results support the use of bright light as an adjunct treatment to antidepressants in non-seasonal depression.
强光疗法是治疗季节性情感障碍的一种既定疗法，但在非季节性抑郁症的研究中结果却相互矛盾。
本研究设计为一项为期5周的对照、双盲、平行试验，研究对象为门诊诊断为（DSM-IV）非季节性重度抑郁症的患者，随机分为积极治疗组（白光，10000勒克斯，每日1小时）或安慰剂治疗组（红光，50勒克斯，每日30分钟），两组均同时服用舍曲林。
102名患者纳入研究。分析表明，在所有使用的量表上，强光组的抑郁评分降低幅度均大于暗光组，且在所有观察者评定量表和SCL-90R自评量表上均达到统计学显著差异。HAM-D6是测量终点改善情况最敏感的量表。
研究结果支持在非季节性抑郁症中使用强光作为抗抑郁药的辅助治疗。
