Steininger Christoph, Kundi Michael, Kletzmayr Josef, Aberle Stephan W, Popow-Kraupp Theresia
Department of Medicine I, Infectious Diseases Unit, University Clinic Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.
J Infect Dis. 2004 Dec 1;190(11):1908-12. doi: 10.1086/424677. Epub 2004 Oct 27.
To investigate antibody maturation and serum levels of cytomegalovirus (CMV) DNA after primary CMV infection, we studied 51 immunocompetent and 27 kidney-transplant patients. Compared with the immunocompetent patients, the transplant patients had significantly more-prolonged and -variable antibody maturation, clearly longer durations of viremia, and higher levels of CMV DNA; however, antibody maturation continued for >1 year even in immunocompetent patients. Long-term ganciclovir prophylaxis in the transplant patients was associated with either delayed immunoglobulin-G seroconversion, inhibition of antibody maturation (n=2), or immunoglobulin-class switching (n=1). In conclusion, antibody maturation continues in immunocompetent patients for a period longer than previously had been thought and is significantly delayed or even inhibited in kidney-transplant patients.
为了研究原发性巨细胞病毒（CMV）感染后抗体成熟情况以及血清CMV DNA水平，我们对51名免疫功能正常的患者和27名肾移植患者进行了研究。与免疫功能正常的患者相比，移植患者的抗体成熟时间明显延长且变化更大，病毒血症持续时间明显更长，CMV DNA水平更高；然而，即使是免疫功能正常的患者，抗体成熟也持续了超过1年。移植患者长期使用更昔洛韦预防与免疫球蛋白G血清转化延迟、抗体成熟受抑制（n = 2）或免疫球蛋白类别转换（n = 1）有关。总之，免疫功能正常的患者抗体成熟持续时间比之前认为的更长，而肾移植患者的抗体成熟则明显延迟甚至受到抑制。
