Haya-Fernández María C, Bagán J V, Murillo-Cortés J, Poveda-Roda R, Calabuig C
University General Hospital, Valencia, Spain.
Oral Dis. 2004 Nov;10(6):346-8. doi: 10.1111/j.1601-0825.2004.01031.x.
To determine the relationship between oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC), and to evaluate possible differences between those carcinomas with and without associated leukoplakia.
A total of 138 patients were studied at the Stomatology Service of the University General Hospital, Valencia, Spain. These patients were divided into two groups: group 1, patients with oral cancer and leukoplakia, and group 2, patients with OSCC but with no associated premalignant lesions. The relationship between this precancerous lesion and the OSCC was evaluated, as well as the possible clinical and histological differences between the tumours of the two groups.
Leukoplakia was detected in 27 (19.56%) patients with OSCC. No differences were found between the two groups regarding age and tumour location. However, statistically significant differences were observed with respect to the form, tumour stage and the presence of adenopathies in the cancers with and without leukoplakia; in that the tumours associated with leukoplakia were diagnosed as being at a more initial stage.
Those patients with OL associated with oral cancer presented with tumours at a less advanced stage than those where no associated leukoplakia existed.
确定口腔白斑（OL）与口腔鳞状细胞癌（OSCC）之间的关系，并评估伴有和不伴有相关白斑的癌症之间可能存在的差异。
在西班牙巴伦西亚大学综合医院口腔科对138例患者进行了研究。这些患者被分为两组：第1组，患有口腔癌和白斑的患者；第2组，患有OSCC但无相关癌前病变的患者。评估了这种癌前病变与OSCC之间的关系，以及两组肿瘤之间可能存在的临床和组织学差异。
在138例OSCC患者中，有27例（19.56%）检测到白斑。两组在年龄和肿瘤位置方面未发现差异。然而，在伴有和不伴有白斑的癌症中，在形态、肿瘤分期和淋巴结病的存在方面观察到统计学上的显著差异；与白斑相关的肿瘤被诊断为处于更早期阶段。
与口腔癌相关的OL患者所患肿瘤的分期比无相关白斑的患者更早期。
