Irwin M, Smith T L, Gillin J C
Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla.
Psychosom Med. 1992 Jan-Feb;54(1):10-21. doi: 10.1097/00006842-199201000-00002.
Insomnia is associated with a reduction of natural killer (NK) activity in depression independent of the severity of other depressive symptoms. This study extends these findings by exploring the relationship between objective electroencephalographic (EEG) assessment of sleep and values of NK activity in depressed patients (n = 23) and in control subjects (n = 17). The sleep EEG parameters total sleep time, sleep efficiency, and duration of nonREM sleep were each positively correlated with NK activity in the depressed patients and in the control subjects, demonstrating similar relationships between the amount of sleep and NK activity in the separate groups. These observations support the hypothesis that sleep measures are associated with NK cytotoxicity, independent of the effects of severity of depressive symptoms or the presence of a mood disorder.
失眠与抑郁症患者自然杀伤细胞（NK）活性降低有关，且与其他抑郁症状的严重程度无关。本研究通过探讨抑郁患者（n = 23）和对照受试者（n = 17）的睡眠客观脑电图（EEG）评估与NK活性值之间的关系，扩展了这些发现。抑郁患者和对照受试者的睡眠EEG参数总睡眠时间、睡眠效率和非快速眼动睡眠持续时间均与NK活性呈正相关，表明不同组中睡眠量与NK活性之间存在相似关系。这些观察结果支持了这样一种假设，即睡眠指标与NK细胞毒性相关，与抑郁症状严重程度的影响或情绪障碍的存在无关。
