Blaes F, Schmitz K, Tschernatsch M, Kaps M, Krasenbrink I, Hempelmann G, Bräu M E
Department of Neurology, Justus-Liebig-University, Am Steg 14, 35385 Giessen, Germany.
Neurology. 2004 Nov 9;63(9):1734-6. doi: 10.1212/01.wnl.0000143066.58498.ba.
Sera of 12 patients with complex regional pain syndrome (CRPS) were tested for the occurrence of autoantibodies against nervous system structures. Immunohistochemistry revealed autoantibodies against autonomic nervous system structures in 5 of 12 (41.6%) of the patients. Western blot analysis showed neuronal reactivity in 11 of 12 (91.6%) patients. The authors hypothesize that CRPS can result from an autoimmune process against the sympathetic nervous system.
对12例复杂性区域疼痛综合征（CRPS）患者的血清进行检测，以确定是否存在针对神经系统结构的自身抗体。免疫组织化学显示，12例患者中有5例（41.6%）存在针对自主神经系统结构的自身抗体。蛋白质印迹分析显示，12例患者中有11例（91.6%）出现神经元反应性。作者推测，CRPS可能是由针对交感神经系统的自身免疫过程引起的。
