Poyatos Juan F, Hurst Laurence D
Evolutionary Systems Biology Initiative, Structural and Computational Biology Program, Spanish National Cancer Center (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain.
Genome Biol. 2004;5(11):R93. doi: 10.1186/gb-2004-5-11-r93. Epub 2004 Nov 1.
By applying a graph-based algorithm to yeast protein-interaction networks we have extracted modular structures and show that they can be validated using information from the phylogenetic conservation of the network components. We show that the module cores, the parts with the highest intramodular connectivity, are biologically relevant components of the networks. These constituents correlate only weakly with other levels of organization. We also discuss how such structures could be used for finding targets for antimicrobial drugs.
通过将基于图的算法应用于酵母蛋白质相互作用网络，我们提取了模块化结构，并表明可以利用网络组件的系统发育保守性信息对其进行验证。我们表明，模块核心，即模块内连通性最高的部分，是网络中具有生物学相关性的组件。这些组成部分与其他组织层次的相关性较弱。我们还讨论了如何利用这些结构来寻找抗菌药物的靶点。
