Otsuki M, Sakamoto C, Ohki A, Yuu H, Baba S
Horm Metab Res. 1981 Feb;13(2):80-4. doi: 10.1055/s-2007-1019179.
Pancreatic juice flow and amylase output, and the concentrations of immunoreactive secretin in portal and peripheral blood were simultaneously determined in anesthetized rats in response to intraduodenal instillation of 1-phenyl-1-hydroxy-n-pentane (PHP), a phenyl carbinol derivative induced from one of the constituents of Curcuma. PHP stimulated both pancreatic juice flow and amylase output and increased portal and jugular plasma secretin levels in a dose-related fashion. During intraduodenal instillation of PHP the pH in the second portion of the duodenum remained consistently above 6.3. Infusion of cyclic somatostatin at a dose of 5 microgram/kg/h significantly suppressed the PHP-induced secretin release, though pancreatic flow rate and amylase output were only slightly and insignificantly suppressed. These observations suggest that PHP release secretin by an acid independent mechanism but also stimulates the exocrine pancreas by a mechanism independent of secretin.
在麻醉大鼠中，通过十二指肠内滴注1-苯基-1-羟基正戊烷（PHP，一种从姜黄成分中诱导产生的苯基甲醇衍生物），同时测定胰液分泌量、淀粉酶分泌量以及门静脉血和外周血中免疫反应性促胰液素的浓度。PHP以剂量相关的方式刺激胰液分泌和淀粉酶分泌，并提高门静脉和颈静脉血浆中促胰液素水平。在十二指肠内滴注PHP期间，十二指肠第二段的pH值始终保持在6.3以上。以5微克/千克/小时的剂量输注环孢素显著抑制了PHP诱导的促胰液素释放，尽管胰液流速和淀粉酶分泌量仅受到轻微且不显著的抑制。这些观察结果表明，PHP通过一种不依赖于酸的机制释放促胰液素，但也通过一种独立于促胰液素的机制刺激外分泌胰腺。
