Johansson C, Mellström D, Lerner U, Osterberg T
Department of Geriatric Medicine, Vasa Hospital, Gothenburg, Sweden.
Age Ageing. 1992 Jan;21(1):20-6. doi: 10.1093/ageing/21.1.20.
The influence of coffee drinking as a possible risk factor for loss of bone mass was assessed in a cohort of 619 70-year-old men and women who were examined with dual photon absorptiometry of the right calcaneum. A high consumption of coffee was significantly associated with a lower bone mass, deteriorated dental state, lower socio-economic level and a higher consumption of tobacco. In non-smoking women a bivariate relationship was found between the daily consumption of three or more cups of coffee and a low bone mass (p less than 0.01). However, in a stepwise logistic regression model, only tobacco smoking, body mass index, body height, physical activity and a deteriorated dental state were found to be significant predictive factors for a low bone mineral content. Bone mass and tobacco smoking were the only significant predictive factors for fractures before the ages of 70 and 76 years. Coffee drinking was not a contributory independent risk factor for loss of bone mass and fractures in this population study.
在一项对619名70岁男性和女性进行的队列研究中，评估了喝咖啡作为骨量流失潜在风险因素的影响。这些人接受了右跟骨双能光子吸收测定。大量饮用咖啡与较低的骨量、较差的牙齿状况、较低的社会经济水平以及较高的烟草消费量显著相关。在不吸烟的女性中，发现每天饮用三杯或更多杯咖啡与低骨量之间存在双变量关系（p<0.01）。然而，在逐步逻辑回归模型中，仅发现吸烟、体重指数、身高、身体活动和较差的牙齿状况是低骨矿物质含量的显著预测因素。骨量和吸烟是70岁和76岁之前骨折的仅有的显著预测因素。在这项人群研究中，喝咖啡并非骨量流失和骨折的独立风险因素。
