Guzowski John F, Knierim James J, Moser Edvard I
Department of Neurosciences, University of New Mexico HSC, Albuquerque, NM 87131, USA.
Neuron. 2004 Nov 18;44(4):581-4. doi: 10.1016/j.neuron.2004.11.003.
Computational models based on hippocampal connectivity have proposed that CA3 is uniquely positioned as an autoassociative memory network, capable of performing the competing functions of pattern completion and pattern separation. Recently, three independent studies, two using parallel neurophysiological recording methods and one using immediate-early gene imaging, have examined the responses of CA3 and CA1 ensembles to alterations of environmental context in rats. The results provide converging evidence that CA3 is capable of performing nonlinear transformations of sensory input patterns, whereas CA1 may represent changes in input in a more linear fashion.
基于海马体连接性的计算模型提出，CA3作为一个自联想记忆网络具有独特的地位，能够执行模式完成和模式分离这两种相互竞争的功能。最近，三项独立研究对大鼠CA3和CA1神经元集群对环境背景变化的反应进行了研究，其中两项采用并行神经生理学记录方法，一项采用即刻早期基因成像技术。结果提供了一致的证据，表明CA3能够对感觉输入模式进行非线性转换，而CA1可能以更线性的方式表征输入的变化。
