Heath Emily, Seuntjens Jan, Sheikh-Bagheri Daryoush
McGill University, Montreal H3G 1A4, Canada.
Med Phys. 2004 Oct;31(10):2771-9. doi: 10.1118/1.1786172.
In this work we dosimetrically evaluated the clinical implementation of a commercial Monte Carlo treatment planning software (PEREGRINE, North American Scientific, Cranberry Township, PA) intended for quality assurance (QA) of intensity modulated radiation therapy treatment plans. Dose profiles calculated in homogeneous and heterogeneous phantoms using this system were compared to both measurements and simulations using the EGSnrc Monte Carlo code for the 6 MV beam of a Varian CL21EX linear accelerator. For simple jaw-defined fields, calculations agree within 2% of the dose at d(max) with measurements in homogeneous phantoms with the exception of the buildup region where the calculations overestimate the dose by up to 8%. In heterogeneous lung and bone phantoms the agreement is within 3%, on average, up to 5% for a 1 x 1 cm2 field. We tested two consecutive implementations of the MLC model. After matching the calculated and measured MLC leakage, simulations of static and dynamic MLC-defined fields using the most recent MLC model agreed to within 2% with measurements.
在本研究中，我们对一款用于调强放射治疗计划质量保证（QA）的商业蒙特卡罗治疗计划软件（PEREGRINE，北美科学公司，宾夕法尼亚州克兰伯里镇）的临床应用进行了剂量学评估。使用该系统在均匀和非均匀体模中计算的剂量分布与使用EGSnrc蒙特卡罗代码对Varian CL21EX直线加速器的6 MV射束进行的测量和模拟结果进行了比较。对于简单的限束器定义野，在均匀体模中，计算结果与测量值在d(max)处的剂量相差在2%以内，但在剂量建成区，计算值高估剂量高达8%。在非均匀的肺和骨体模中，平均一致性在3%以内，对于1×1 cm2的射野，一致性高达5%。我们测试了多叶准直器（MLC）模型的两个连续版本。在使计算得到的和测量得到的MLC漏射线匹配之后，使用最新MLC模型对静态和动态MLC定义野进行的模拟与测量结果相差在2%以内。
