Tabrizi Chakameh Azimpour, Walcher Petra, Mayr Ulrike Beate, Stiedl Thomas, Binder Matthias, McGrath John, Lubitz Werner
Institute of Microbiology and Genetics, Section Microbiology and Biotechnology, University of Vienna, Althanstrasse 14, UZAII, 2B 522, A-1090 Vienna, Austria.
Curr Opin Biotechnol. 2004 Dec;15(6):530-7. doi: 10.1016/j.copbio.2004.10.004.
Despite the exponential rate of discovery of new antigens and DNA vaccines resulting from modern molecular biology and proteomics, the lack of effective delivery technology is a major limiting factor in their application. The bacterial ghost system represents a platform technology for antigen, nucleic acid and drug delivery. Bacterial ghosts have significant advantages over other engineered biological delivery particles, owing to their intrinsic cellular and tissue tropic abilities, ease of production and the fact that they can be stored and processed without the need for refrigeration. These particles have found both veterinary and medical applications for the vaccination and treatment of tumors and various infectious diseases.
尽管现代分子生物学和蛋白质组学使得新抗原和DNA疫苗的发现呈指数级增长，但缺乏有效的递送技术是其应用的主要限制因素。细菌幽灵系统是一种用于抗原、核酸和药物递送的平台技术。细菌幽灵比其他工程化生物递送颗粒具有显著优势，这得益于其固有的细胞和组织靶向能力、易于生产，以及无需冷藏即可储存和处理的特性。这些颗粒已在兽医和医学领域用于肿瘤及各种传染病的疫苗接种和治疗。
