Malagon C, Van Kerckhove C, Giannini E H, Taylor J, Lovell D J, Levinson J E, Passo M H, Ginsberg J, Burke M J, Glass D N
Children's Hospital Medical Center, Cincinnati, OH 45229-2899.
J Rheumatol. 1992 Jan;19(1):160-3.
In a cohort of 72 patients with iridocyclitis (iritis) and early onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA) the course of the eye disease was matched with ocular outcome. Chronicity of inflammation (greater than 6 months/episode) was correlated with complications of eye disease that caused impairment of vision. HLA antigens in these patients were compared with the HLA antigens in a cohort of 77 patients with EOPA-JRA in whom iridocyclitis had failed to develop over a followup of 5 years or longer. HLA-DR5 (11) was correlated with the presence of eye disease, and HLA-DR1 with its absence; HLA-DRw8, which strongly predisposes to EOPA-JRA, was neutral with respect to eye disease.
在一个由72例虹膜睫状体炎（虹膜炎）和早发性少关节型幼年类风湿性关节炎（EOPA-JRA）患者组成的队列中，眼部疾病的病程与眼部结局相匹配。炎症的慢性化（每次发作超过6个月）与导致视力损害的眼部疾病并发症相关。将这些患者的HLA抗原与一组77例EOPA-JRA患者的HLA抗原进行比较，这些EOPA-JRA患者在5年或更长时间的随访中未发生虹膜睫状体炎。HLA-DR5（11）与眼部疾病的存在相关，而HLA-DR1与眼部疾病的不存在相关；强烈易患EOPA-JRA的HLA-DRw8在眼部疾病方面呈中性。
