Hamkar R, Azad T Mokhtari, Mahmoodi M, Seyedirashti S, Severini A, Nategh R
Division of Virology, Department of Pathobiology, School of Public Health, Institute of Public Health Research, Teheran University of Medical Sciences, Teheran, Islamic Republic of Iran.
East Mediterr Health J. 2002 Nov;8(6):805-11.
We report the prevalence of human papillomavirus (HPV) types in 100 cervical biopsy specimens in Mazandaran province. HPV DNA was detected in 78.6% of cervical carcinoma cases, 64.3% of dys/ metaplasia and 9% of normal cases. Significant correlation was found between the presence of HPV DNA and development of cervical carcinoma. HPV types 16 and 18 were detected in 60.6% of HPV-positive cervical carcinoma cases, whereas HPV31 and 33 were found in 21.2%, and HPV6 and 11 in 18.2%. Among HPV-positive dys/metaplasia cases, 55.6% were positive for HPV16 and 18, 22.3% for HPV6 and 11, and 11.1% for HPV31 and 33. Only HPV6 and 11 were detected in 4 (100%) normal biopsy specimens.
我们报告了马赞德兰省100份宫颈活检标本中人类乳头瘤病毒（HPV）各型别的流行情况。在78.6%的宫颈癌病例、64.3%的发育异常/化生病例以及9%的正常病例中检测到了HPV DNA。发现HPV DNA的存在与宫颈癌的发生之间存在显著相关性。在60.6%的HPV阳性宫颈癌病例中检测到了HPV16和18型，而在21.2%的病例中发现了HPV31和33型，在18.2%的病例中发现了HPV6和11型。在HPV阳性的发育异常/化生病例中，55.6%为HPV16和18型阳性，22.3%为HPV6和11型阳性，11.1%为HPV31和33型阳性。在4份（100%）正常活检标本中仅检测到了HPV6和11型。
