Tsukamoto Sachiko, Tomise Kyoko, Aburatani Maki, Onuki Hiroyuki, Hirorta Hiroshi, Ishiharajima Eiji, Ohta Tomihisa
Faculty of Pharmaceutical Sciences, Kanazawa University, Takara-machi, Kanazawa 920-0934, Japan.
J Nat Prod. 2004 Nov;67(11):1839-41. doi: 10.1021/np0400104.
A new glycoside, 2-beta-d-glucopyranosyloxy-4,6-dihydroxyisovalerophenone (3), was isolated from strawberry fruit along with kaempferol-3-beta-D-(6-O-trans-p-coumaroyl)glucopyranoside (1) and kaempferol-3-beta-D-(6-O-cis-p-coumaroyl)glucopyranoside (2). Compounds 1 and 2 inhibited activity of a drug-metabolizing enzyme, CYP3A4.
从草莓果实中分离出一种新的糖苷，2-β-D-吡喃葡萄糖氧基-4,6-二羟基异戊酰苯（3），以及山奈酚-3-β-D-（6-O-反式对香豆酰基）吡喃葡萄糖苷（1）和山奈酚-3-β-D-（6-O-顺式对香豆酰基）吡喃葡萄糖苷（2）。化合物1和2抑制药物代谢酶CYP3A4的活性。
