Parish Craig A, Huber Joann, Baxter Jenny, González Antonio, Collado Javier, Platas Gonzalo, Diez Maria Teresa, Vicente Francisca, Dorso Karen, Abruzzo George, Wilson Kenneth
Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065-0900, USA.
J Nat Prod. 2004 Nov;67(11):1900-2. doi: 10.1021/np0497853.
The isolation and structure elucidation of 1 from the Basidomycete fungus Baeospora myosura is described. This new ene-triyne antibiotic was most potent against Gram-positive bacteria, while it was less active against Gram-negative bacteria and a yeast. MICs against several strains of Staphylococcus aureus were as low as 0.001 microg/mL. Analogues of 1 that did not contain the ene-triyne moiety were inactive against all microorganisms tested. The isolation of this new natural product was complicated by the highly reactive nature of the conjugated terminal polyacetylene.
本文描述了从担子菌纲真菌肉色被孢霉中分离出化合物1并阐明其结构的过程。这种新型烯三炔抗生素对革兰氏阳性菌的活性最强，而对革兰氏阴性菌和一种酵母的活性较弱。对几株金黄色葡萄球菌的最低抑菌浓度低至0.001微克/毫升。不含烯三炔部分的1的类似物对所有测试微生物均无活性。由于共轭末端聚乙炔具有高反应活性，这种新天然产物的分离过程较为复杂。
