Troprès I, Lamalle L, Farion R, Segebarth C, Rémy C
IFR1, Unité IRM 3T, Centre Hospitalier Universitaire, 38043, Grenoble CEDEX 9, France.
MAGMA. 2004 Dec;17(3-6):313-6. doi: 10.1007/s10334-004-0067-3. Epub 2004 Dec 1.
Vessel size index (VSI) measurements have been validated on rats bearing a glioma with high doses of contrast agent. The aim of this study was to evaluate the impact of using a reduced dose of contrast agent, necessary for clinical trials. Experiments were performed on rats at three doses of AMI-227 and clearly show higher VSI values at lower doses, whatever the region of interest (contralateral, peritumoral and intratumoral tissue). These results are in good correlation with Monte-Carlo simulations on healthy brain and suggest that only relative values can be obtained at clinical contrast agent doses and magnetic fields.
血管大小指数（VSI）测量已在高剂量造影剂的荷胶质瘤大鼠身上得到验证。本研究的目的是评估使用临床试验所需的较低剂量造影剂的影响。对大鼠进行了三种剂量的AMI - 227实验，结果清楚地表明，无论感兴趣区域（对侧、瘤周和瘤内组织）如何，较低剂量时VSI值更高。这些结果与健康大脑的蒙特卡罗模拟结果高度相关，表明在临床造影剂剂量和磁场条件下只能获得相对值。
