Park Young Kyu, Kim Dong Yi, Joo Jae Kyoon, Kim Jung Chul, Koh Yang Suk, Ryu Seong Yeob, Kim Young Jin, Kim Shin Kon
Division of Gastroenterologic Surgery, Department of Surgery, Chonnam National University Medical School, 8, Hakdong, Dongku, Gwangju, 501-757, South Korea.
Langenbecks Arch Surg. 2005 Aug;390(4):300-5. doi: 10.1007/s00423-004-0525-4. Epub 2004 Dec 15.
Multiple primary carcinomas are increasingly being found because of the development of diagnostic techniques and the increasing incidence of early stage carcinoma. The purpose of this study was to determine the prevalence and clinicopathological features of gastric carcinoma patients with other primary carcinomas.
There were 65 (incidence 2.6%) gastric carcinoma patients with other primary carcinomas compared with 2,444 patients with gastric carcinoma alone.
Associated primary carcinomas were often found in the gastrointestinal (GI) tract, especially in the colon (33.8%). In patients with gastric carcinoma only, poorly differentiated adenocarcinoma was the most common (43.2%), followed by moderately and well-differentiated adenocarcinoma. Similarly, poorly differentiated adenocarcinoma (33.8%) was also the prevalent histological type in gastric carcinoma patients with other primary carcinomas, although its incidence was lower. The stage of gastric carcinoma did not differ between the two groups. The estimated 5-year survival rate was 51.6% for patients with gastric carcinoma alone, and 50.7% for those with other primary carcinomas; the difference was not significant (P=0.82).
Gastric carcinoma should be treated aggressively, since the prognosis of gastric carcinoma patients treated for other primary carcinomas is not poorer than that of patients treated for gastric carcinoma alone.
由于诊断技术的发展和早期癌症发病率的上升，多原发性癌越来越多地被发现。本研究的目的是确定患有其他原发性癌的胃癌患者的患病率及临床病理特征。
65例（发病率2.6%）患有其他原发性癌的胃癌患者与2444例单纯胃癌患者进行比较。
相关原发性癌常发生于胃肠道，尤其是结肠（33.8%）。在单纯胃癌患者中，低分化腺癌最为常见（43.2%），其次是中分化和高分化腺癌。同样，低分化腺癌（33.8%）在患有其他原发性癌的胃癌患者中也是最常见的组织学类型，尽管其发生率较低。两组胃癌的分期无差异。单纯胃癌患者的估计5年生存率为51.6%，患有其他原发性癌的患者为50.7%；差异无统计学意义（P=0.82）。
应积极治疗胃癌，因为因其他原发性癌接受治疗的胃癌患者的预后并不比单纯接受胃癌治疗的患者差。
