阿尔茨海默病进展过程中内侧颞叶的萎缩率
Atrophy rate in medial temporal lobe during progression of Alzheimer disease.
作者信息
Rusinek H, Endo Y, De Santi S, Frid D, Tsui W-H, Segal S, Convit A, de Leon M J
机构信息
Department of Radiology, NYU School of Medicine, Bellevue Old C&D Bldg., Rm. D120, 550 First Avenue, New York, NY 10016, USA.
出版信息
Neurology. 2004 Dec 28;63(12):2354-9. doi: 10.1212/01.wnl.0000148602.30175.ac.
OBJECTIVE
To establish the progression of brain atrophy rates in patients with a known date of onset of Alzheimer disease (AD).
METHODS
Each of 18 subjects had two high-resolution T1-weighted three-dimensional MRI examinations. The two MRIs were coregistered and the annual rate of brain tissue atrophy was derived both for the entire brain and regionally for the left and right medial temporal lobe (MTL). Time since onset (TSO) of AD, defined as the interval between the date of onset and the midpoint of MRI dates, ranged from -2.9 to 4.2 years.
RESULTS
In patients with AD, TSO was a correlate of the atrophy rate for both the left MTL (R2 = 0.58, p = 0.001) and right MTL (R2 = 0.30, p = 0.03). When serial measurements were applied to a control group of 21 cognitively normal elderly subjects, MTL atrophy rate classified the group membership (AD vs normal cognition) with an accuracy of 92.3%.
CONCLUSION
Increased annual atrophy rate in the medial temporal lobe is a potential diagnostic marker of the progression of Alzheimer disease.
目的
确定已知阿尔茨海默病（AD）发病日期患者的脑萎缩率进展情况。
方法
18名受试者每人接受了两次高分辨率T1加权三维MRI检查。对两次MRI进行配准，并得出全脑以及左侧和右侧内侧颞叶（MTL）局部的脑组织年萎缩率。AD发病后的时间（TSO）定义为发病日期与MRI日期中点之间的间隔，范围为-2.9至4.2年。
结果
在AD患者中，TSO与左侧MTL（R2 = 0.58，p = 0.001）和右侧MTL（R2 = 0.30，p = 0.03）的萎缩率均相关。当对21名认知正常的老年受试者组成的对照组进行系列测量时，MTL萎缩率对该组成员（AD与正常认知）的分类准确率为92.3%。
结论
内侧颞叶年萎缩率增加是阿尔茨海默病进展的潜在诊断标志物。
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