荷兰献血者中的细小病毒B19病毒血症
Parvovirus B19 viraemia in Dutch blood donors.
作者信息
Zaaijer H L, Koppelman M H G M, Farrington C P
机构信息
Sanquin, Central Laboratory of The Netherlands Blood Transfusion Service, Amsterdam, The Netherlands.
出版信息
Epidemiol Infect. 2004 Dec;132(6):1161-6. doi: 10.1017/s0950268804002730.
Blood, donated by asymptomatic donors, may contain and transmit parvovirus B19. To investigate the dynamics of parvovirus viraemia in asymptomatic blood donors, we studied the amounts of parvovirus DNA in pools of donor plasma, the prevalence of parvovirus antibodies among blood donors in relation to age, and the seasonal and year-to-year variation of the incidence of parvovirus infection in The Netherlands. The incidence of parvovirus infection follows a seasonal cycle and a cycle of several years. Among Dutch blood donors the incidence was estimated to be 0.56% per year. Forty seven out of 100 pools of 5000 plasma donations tested positive for parvovirus DNA. We inferred that the course of viraemia in asymptomatic donors shows a short peak (> 10(9) copies parvovirus DNA/ml), followed by viraemia below 10(6) copies/ml for about 2 weeks.
由无症状献血者捐献的血液可能含有并传播细小病毒B19。为了研究无症状献血者中细小病毒血症的动态变化，我们研究了献血者血浆池中细小病毒DNA的含量、献血者中细小病毒抗体的流行率与年龄的关系，以及荷兰细小病毒感染发病率的季节性和逐年变化。细小病毒感染的发病率呈现季节性周期和数年的周期。在荷兰献血者中，估计发病率为每年0.56%。在检测的100组5000份血浆捐献中，有47组细小病毒DNA检测呈阳性。我们推断，无症状献血者的病毒血症过程显示出一个短暂的峰值（>10⁹拷贝细小病毒DNA/毫升），随后病毒血症低于10⁶拷贝/毫升约2周。
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