Fischer Axel, Wussow Anke, Cryer Annette, Schmeck Bernd, Noga Oliver, Zweng Martina, Peiser Christian, Dinh Q Thai, Heppt Werner, Groneberg David A
Occupational and Environmental Medicine Research Unit, Division of Allergy Research, Otto-Heubner-Centre, Charité School of Medicine, Free University and Humboldt-University, Berlin, Germany.
J Occup Environ Med. 2005 Jan;47(1):20-5. doi: 10.1097/01.jom.0000150238.77663.49.
Persistent perennial allergic rhinitis belongs to the most frequent diseases in occupational and environmental medicine. Because the innervation may play a role in the pathogenesis of the disease, the present study analyzed nasal mucosal nerve profiles.
Neuropeptide-containing nerve fibers were examined using immunohistochemistry and related to eosinophil and mast cell numbers.
In contrast to constant numbers of mast cells, there was a significant increase in the number of eosinophils. Immunohistochemistry for calcitonin gene-related peptide (CGRP), substance P (SP), vasoactive intestinal peptide (VIP), and neuropeptide tyrosine (NPY) revealed abundant staining of mucosal nerves. Semiquantitative assessment of nerve fiber neuropeptide density demonstrated a significant increase of VIP-positive fibers in rhinitis tissues.
The present data indicate a differential regulation of neuropeptide-containing nerve fibers with increased numbers of VIPergic fibers suggesting a modulatory role of the upper airway innervation in perennial allergic rhinitis.
持续性常年性变应性鼻炎属于职业与环境医学中最常见的疾病。由于神经支配可能在该疾病的发病机制中起作用，本研究分析了鼻黏膜神经分布情况。
采用免疫组织化学方法检测含神经肽的神经纤维，并与嗜酸性粒细胞和肥大细胞数量相关联。
与肥大细胞数量恒定不同，嗜酸性粒细胞数量显著增加。降钙素基因相关肽（CGRP）、P物质（SP）、血管活性肠肽（VIP）和神经肽Y（NPY）的免疫组织化学显示黏膜神经有丰富的染色。对神经纤维神经肽密度的半定量评估表明，鼻炎组织中VIP阳性纤维显著增加。
目前的数据表明含神经肽的神经纤维存在差异调节，VIP能纤维数量增加提示上呼吸道神经支配在常年性变应性鼻炎中起调节作用。
