Nam Myung Hee, Kim Seung Il, Liu Jang Ryol, Yang Deok Chun, Lim Yong Pyo, Kwon Kyung-Hoon, Yoo Jong Shin, Park Young Mok
Metabolome Analysis Team, Korea Basic Science Institute, Seoul 136-701, Korea.
J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 5;815(1-2):147-55. doi: 10.1016/j.jchromb.2004.10.063.
Although many reports have been published regarding the pharmacological effects of ginseng, little is known about the biochemical pathways operant in ginsenoside biosynthesis, or the genes involved therein. Proteomics analysis is an approach to elucidate the physiological characteristics and biosynthetic pathways of ginsenosides, main components of ginseng. In this review, we introduced the recent progress in proteomics studies of ginseng (Panax ginseng C.A. Meyer). We briefly reference the genomic analyses of P. ginseng, without which proteomics approaches would have been impossible. Functional genomics studies regarding secondary metabolism in P. ginseng are also introduced here, in order to introduce possible future prospects for further study.
尽管已经发表了许多关于人参药理作用的报告,但对于人参皂苷生物合成中起作用的生化途径或其中涉及的基因却知之甚少。蛋白质组学分析是一种阐明人参主要成分人参皂苷的生理特性和生物合成途径的方法。在这篇综述中,我们介绍了人参(Panax ginseng C.A. Meyer)蛋白质组学研究的最新进展。我们简要提及了人参的基因组分析,没有这些分析,蛋白质组学方法将无法实现。这里还介绍了关于人参次生代谢的功能基因组学研究,以便介绍未来进一步研究的可能前景。