Peter B, Pioletti D P, Laïb S, Bujoli B, Pilet P, Janvier P, Guicheux J, Zambelli P-Y, Bouler J-M, Gauthier O
Bone Bioengineering Group, Laboratory of Orthopedic Research, Swiss Federal Institute of Technology Lausanne, Switzerland.
Bone. 2005 Jan;36(1):52-60. doi: 10.1016/j.bone.2004.10.004. Epub 2004 Nov 23.
Despite total hip replacement (THR) gives generally satisfactory results, the quality of outcome in young patients is markedly decreased compared to the average THR outcome. For this population, pharmacological treatment with bisphosphonate would be beneficial to decrease the peri-implant osteolysis. However, as this population does not necessarily suffer from osteoporosis, a nonsystemic treatment would be preferable. Zoledronate was then grafted to hydroxyapatite (HA) coating of titanium implants. The implants were inserted in rat condyles with various zoledronate concentrations. A positive concentration-dependent effect was observed on the peri-implant bone density and on different histomorphometric parameters. Importantly for the outcome of the implants, the mechanical fixation was increased by the local presence of zoledronate. The obtained results open the way of an easy transformation of currently existing HA-coated implants by grafting bisphosphonate onto the coating in order to increase their service life in the patients.
尽管全髋关节置换术（THR）总体上能取得令人满意的效果，但与平均THR结果相比，年轻患者的手术效果质量明显下降。对于这一人群，使用双膦酸盐进行药物治疗有助于减少植入物周围的骨溶解。然而，由于这一人群不一定患有骨质疏松症，非全身性治疗更为可取。于是将唑来膦酸接枝到钛植入物的羟基磷灰石（HA）涂层上。将不同唑来膦酸浓度的植入物植入大鼠髁突。观察到植入物周围骨密度和不同组织形态计量学参数呈现出浓度依赖性的积极效应。对于植入物的效果而言，重要的是唑来膦酸的局部存在增加了机械固定。所获得的结果为通过将双膦酸盐接枝到涂层上对现有HA涂层植入物进行简便改造开辟了道路，从而提高其在患者体内的使用寿命。
