使用壳聚糖-海藻酸盐凝胶/间充质干细胞/BMP-2复合材料的可注射骨。
Injectable bone using chitosan-alginate gel/mesenchymal stem cells/BMP-2 composites.
作者信息
Park Dong-Joon, Choi Byung-Ho, Zhu Shi-Jiang, Huh Jin-Young, Kim Byung-Young, Lee Seoung-Ho
机构信息
Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, South Korea.
出版信息
J Craniomaxillofac Surg. 2005 Feb;33(1):50-4. doi: 10.1016/j.jcms.2004.05.011. Epub 2005 Jan 11.
AIM
Several injectable materials have been used as osteogenic bone substitutes. However, none has gained universal acceptance. This study was performed to investigate whether or not chitosan-alginate gel/mesenchymal stem cells/bone morphogenetic protein-2 composites are potentially injectable materials for new bone formation.
MATERIAL AND METHODS
The composites were injected into the subcutaneous space on the dorsum of nude mice to investigate new bone tissue formation. The composites were examined histologically over a 12-week period.
RESULTS
The composites injected into the mouse were able to stimulate new bone formation, which was trabecular in type.
CONCLUSIONS
This study showed that chitosan-alginate gel/MSCs/BMP-2 composites could become clinically useful injectable materials to generate new bone.
目的
几种可注射材料已被用作成骨性骨替代物。然而，没有一种获得普遍认可。进行本研究以调查壳聚糖 - 海藻酸盐凝胶/间充质干细胞/骨形态发生蛋白 - 2复合材料是否为用于新骨形成的潜在可注射材料。
材料与方法
将复合材料注射到裸鼠背部的皮下空间，以研究新骨组织的形成。在12周的时间内对复合材料进行组织学检查。
结果
注射到小鼠体内的复合材料能够刺激新骨形成，新骨为小梁骨类型。
结论
本研究表明壳聚糖 - 海藻酸盐凝胶/间充质干细胞/骨形态发生蛋白 - 2复合材料可成为临床上用于生成新骨的有用可注射材料。
Zotero 插件