School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian 223003, China.
Tecnologico de Monterrey, School of Engineering and Sciences, Campus Monterrey, Ave. Eugenio Garza Sada 2501, Monterrey 64849, Mexico.
Mar Drugs. 2019 Dec 19;18(1):7. doi: 10.3390/md18010007.
Seaweed-derived polysaccharides with unique structural and functional entities have gained special research attention in the current medical sector. Seaweed polysaccharides have been or being used to engineer novel cues with biomedical values to tackle in practice the limitations of counterparts which have become ineffective for 21st-century settings. The inherited features of seaweed polysaccharides, such as those of a biologically tunable, biocompatible, biodegradable, renewable, and non-toxic nature, urge researchers to use them to design therapeutically effective, efficient, controlled delivery, patient-compliant, and age-compliant drug delivery platforms. Based on their significant retention capabilities, tunable active units, swelling, and colloidal features, seaweed polysaccharides have appeared as highly useful materials for modulating drug-delivery and tissue-engineering systems. This paper presents a standard methodological approach to review the literature using inclusion-exclusion criteria, which is mostly ignored in the reported literature. Following that, numerous marine-based seaweed polysaccharides are discussed with suitable examples. For the applied perspectives, part of the review is focused on the biomedical values, i.e., targeted drug delivery, wound-curative potential, anticancer potentialities, tissue-engineering aspects, and ultraviolet (UV) protectant potential of seaweed polysaccharides based engineered cues. Finally, current challenges, gaps, and future perspectives have been included in this review.
具有独特结构和功能实体的海藻衍生多糖在当前医学领域引起了特别的研究关注。海藻多糖已被或正在被用于构建具有生物医学价值的新型信号分子，以解决目前那些在 21 世纪环境下已经失效的对应物的局限性问题。海藻多糖所具有的固有特性，如生物可调性、生物相容性、可生物降解性、可再生性和非毒性等，促使研究人员利用它们来设计治疗效果好、效率高、可控释放、患者依从性和年龄适应性的药物输送平台。基于其显著的保留能力、可调活性单元、溶胀和胶体特性，海藻多糖已成为调节药物输送和组织工程系统的极具应用价值的材料。本文提出了一种标准的文献综述方法，使用了包括-排除标准，但在报道的文献中大多被忽略了。之后，本文讨论了许多基于海洋的海藻多糖，并给出了适当的例子。在应用方面，本文的一部分综述集中在海藻多糖基工程信号分子的生物医学价值上，如靶向药物输送、伤口愈合潜力、抗癌潜力、组织工程方面以及紫外线（UV）保护潜力。最后，本文还包括了当前的挑战、差距和未来展望。
