Marpegán Luciano, Bekinschtein Tristán A, Costas Monica A, Golombek Diego A
Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, R.S. Peña 180, (1876) Bernal, Buenos Aires, Argentina.
J Neuroimmunol. 2005 Mar;160(1-2):102-9. doi: 10.1016/j.jneuroim.2004.11.003. Epub 2004 Dec 28.
We tested the ability of Escherichia coli lipopolysaccharide (LPS) to phase-shift the activity circadian rhythm in C57Bl/6J mice. Intraperitoneal administration of 25 microg/kg LPS induced photic-like phase delays (-43+/-10 min) during the early subjective night. These delays were non-additive to those induced by light at CT 15, and were reduced by the previous administration of sulfasalazine, a NF-kappaB activation inhibitor. At CT 15, LPS induced c-Fos expression in the dorsal area of the suprachiasmatic nuclei (SCN). Our results suggest that the activation of the immune system should be considered an entraining signal for the murine circadian clock.
我们测试了大肠杆菌脂多糖（LPS）使C57Bl/6J小鼠的昼夜节律活动发生相位转移的能力。腹腔注射25微克/千克的LPS在主观夜早期诱导出类似光照的相位延迟（-43±10分钟）。这些延迟与CT15时光照诱导的延迟无累加效应，且在预先给予NF-κB激活抑制剂柳氮磺胺吡啶后延迟减小。在CT15时，LPS诱导视交叉上核（SCN）背侧区域的c-Fos表达。我们的结果表明，免疫系统的激活应被视为小鼠生物钟的一种同步信号。
