Carroll Darin S, Mills James N, Montgomery Joel M, Bausch Daniel G, Blair Patrick J, Burans James P, Felices Vidal, Gianella Alberto, Iihoshi Naomi, Nichol Stuart T, Olson James G, Rogers Duke S, Salazar Milagros, Ksiazek Thomas G
Division of Viral and Rickettsial Diseases, Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Am J Trop Med Hyg. 2005 Jan;72(1):42-6.
In August 2002, two cases of hantavirus pulmonary syndrome (HPS) were confirmed in Mineros and Concepcion, within the Santa Cruz Department of Bolivia. Extensive alteration of the native ecosystem, from dense forest to pasture or sugarcane, had occurred in both regions. An ecologic assessment of reservoir species associated with the human disease identified a single hantavirus antibody-positive Oligoryzomys microtis from Mineros and three hantavirus antibody-positive Calomys callosus from Concepcion. In Mineros, the virus from the O. microtis was 90% similar to sequences published for Rio Mamore virus. Viral nucleotide sequences from two C. callosus were 87-88% similar to the sequence of Laguna Negra virus. The viral sequence from the C. callosus was 99% identical to viral sequences obtained from the HPS patient in this area, implicating C. callosus as the host and Laguna Negra virus as the agent responsible for the HPS case near Concepcion.
2002年8月，在玻利维亚圣克鲁斯省的米内罗斯和康塞普西翁确诊了两例汉坦病毒肺综合征（HPS）病例。这两个地区的原生生态系统都发生了广泛变化，从茂密森林变成了牧场或甘蔗地。一项针对与人类疾病相关的宿主物种的生态评估发现，米内罗斯有一只汉坦病毒抗体呈阳性的小稻鼠，康塞普西翁有三只汉坦病毒抗体呈阳性的南美原鼠。在米内罗斯，从小稻鼠身上分离出的病毒与已公布的马莫雷河病毒序列有90%的相似性。来自两只南美原鼠的病毒核苷酸序列与拉古纳内格拉病毒的序列有87 - 88%的相似性。来自南美原鼠的病毒序列与该地区汉坦病毒肺综合征患者身上获得的病毒序列有99%的同一性，这表明南美原鼠是宿主，拉古纳内格拉病毒是导致康塞普西翁附近汉坦病毒肺综合征病例的病原体。
