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2003年西班牙健康和患病动物大肠杆菌菌株中广谱β-内酰胺酶的监测与特性分析

Monitoring and characterization of extended-spectrum beta-lactamases in Escherichia coli strains from healthy and sick animals in Spain in 2003.

作者信息

Briñas Laura, Moreno Miguel Angel, Teshager Tirushet, Sáenz Yolanda, Porrero María Concepción, Domínguez Lucas, Torres Carmen

机构信息

Area Bioquímica y Biología Molecular, Universidad de La Rioja, Madre de Dios 51, 26006 Logroño, Spain.

出版信息

Antimicrob Agents Chemother. 2005 Mar;49(3):1262-4. doi: 10.1128/AAC.49.3.1262-1264.2005.

DOI:10.1128/AAC.49.3.1262-1264.2005
PMID:15728945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC549238/
Abstract

Genes encoding CTX-M-14, CTX-M-9, CTX-M-1, CTX-M-32, SHV-12, TEM-52, or CMY-2 beta-lactamases were detected in 21 Escherichia coli strains recovered during 2003 from sick animals (11 of 459 [2.4%] strains) and healthy animals (10 of 158 [6.3%] strains) in Spain. Twelve of these strains harbored bla(CTX-M) genes and showed unrelated pulsed-field gel electrophoresis patterns.

摘要

2003年从西班牙患病动物（459株中的11株[2.4%]）和健康动物（158株中的10株[6.3%]）中分离出的21株大肠杆菌中，检测到了编码CTX-M-14、CTX-M-9、CTX-M-1、CTX-M-32、SHV-12、TEM-52或CMY-2β-内酰胺酶的基因。其中12株携带bla(CTX-M)基因，且呈现出不相关的脉冲场凝胶电泳图谱。

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High-level resistance to ceftazidime conferred by a novel enzyme, CTX-M-32, derived from CTX-M-1 through a single Asp240-Gly substitution.一种新型酶CTX-M-32赋予对头孢他啶的高水平耐药性，该酶由CTX-M-1通过单个天冬氨酸240-甘氨酸取代衍生而来。
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Emerg Infect Dis. 2004 Jan;10(1):69-75. doi: 10.3201/eid1001.030219.
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