阿尔茨海默病淀粉样蛋白假说二十年：遗传学视角

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective.

作者信息

Tanzi Rudolph E, Bertram Lars

机构信息

Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Massachussetts General Hospital, Harvard Medical School, Charlestown, Massachussetts 02129, USA.

出版信息

Cell. 2005 Feb 25;120(4):545-55. doi: 10.1016/j.cell.2005.02.008.

DOI:10.1016/j.cell.2005.02.008

PMID:15734686

Abstract

From Alois Alzheimer's description of Auguste D.'s brain in 1907 to George Glenner's biochemical dissection of beta-amyloid in 1984, the "amyloid hypothesis" of Alzheimer's disease has continued to gain support over the past two decades, particularly from genetic studies. Here we assess the amyloid hypothesis based on both known and putative Alzheimer's disease genes.

摘要

从1907年阿洛伊斯·阿尔茨海默对奥古斯特·D.大脑的描述，到1984年乔治·格伦纳对β淀粉样蛋白的生化剖析，在过去二十年里，阿尔茨海默病的“淀粉样蛋白假说”不断获得支持，尤其是来自遗传学研究的支持。在此，我们基于已知的和推测的阿尔茨海默病基因对淀粉样蛋白假说进行评估。