Bassetti Stefano, Bischoff Werner E, Walter Mark, Bassetti-Wyss Barbara A, Mason Lori, Reboussin Beth A, D'Agostino Ralph B, Gwaltney Jack M, Pfaller Michael A, Sherertz Robert J
Section on Infectious Diseases, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Infect Control Hosp Epidemiol. 2005 Feb;26(2):196-203. doi: 10.1086/502526.
To determine whether healthy adult nasal carriers of Staphylococcus aureus can disperse S. aureus into the air after rhinovirus infection.
We investigated the "cloud" phenomenon among adult nasal carriers of S. aureus experimentally infected with a rhinovirus. Eleven volunteers were studied for 16 days in an airtight chamber wearing street clothes, sterile garb, or sterile garb plus surgical mask; rhinovirus inoculation occurred on day 2. Daily quantitative air, nasal, and skin cultures for S. aureus; cold symptom assessment; and nasal rhinovirus cultures were performed.
Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Wake Forest University undergraduate or graduate students who had persistent nasal carriage of S. aureus for 4 or 8 weeks.
After rhinovirus inoculation, dispersal of S. aureus into the air increased 2-fold with peak increases up to 34-fold. Independent predictors of S. aureus dispersal included the time period after rhinovirus infection and wearing street clothes (P < .05). Wearing barrier garb but not a mask decreased dispersal of S. aureus into the air (P < .05).
Virus-induced dispersal of S. aureus into the air may have an important role in the transmission of S. aureus and other bacteria.
确定金黄色葡萄球菌的健康成年鼻腔携带者在感染鼻病毒后是否会将金黄色葡萄球菌散播到空气中。
我们对感染鼻病毒的金黄色葡萄球菌成年鼻腔携带者中的“云雾”现象进行了研究。11名志愿者在密闭舱室中穿着便服、无菌服装或无菌服装加手术口罩进行了16天的研究；在第2天接种鼻病毒。每天对空气中、鼻腔和皮肤进行金黄色葡萄球菌定量培养；评估感冒症状；并进行鼻腔鼻病毒培养。
北卡罗来纳州温斯顿 - 塞勒姆的维克森林大学医学院。
维克森林大学持续4周或8周鼻腔携带金黄色葡萄球菌的本科生或研究生。
接种鼻病毒后，金黄色葡萄球菌向空气中的散播增加了2倍，峰值增加高达34倍。金黄色葡萄球菌散播的独立预测因素包括鼻病毒感染后的时间段和穿着便服（P < 0.05）。穿着隔离服但不戴口罩可减少金黄色葡萄球菌向空气中的散播（P < 0.05）。
病毒诱导的金黄色葡萄球菌向空气中的散播可能在金黄色葡萄球菌和其他细菌的传播中起重要作用。
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