Olofsson Sigvard, Kumlin Urban, Dimock Ken, Arnberg Niklas
Department of Clinical Virology, University of Göteborg, Göteborg, Sweden.
Lancet Infect Dis. 2005 Mar;5(3):184-8. doi: 10.1016/S1473-3099(05)01311-3.
Given our recent discoveries that the ocular human pathogens adenovirus serotype 37 and enterovirus serotype 70 use sialic acid linked to galactose via alpha2,3 glycosidic bonds as a cellular receptor, we propose that the presence of this receptor in the eye also explains the ocular tropism exhibited by zoonotic avian influenza A viruses such as subtype H5N1 in Hong Kong in 1997, H7N7 in the Netherlands in 2003, H7N2 in the USA in 2003, and H7N3 in Canada in 2004. We also draw attention to the implications this hypothesis may have for epizootic and zoonotic influenza, and the initiation of future pandemics.
鉴于我们最近的发现，即人类眼部病原体腺病毒37型和肠道病毒70型利用通过α2,3糖苷键与半乳糖相连的唾液酸作为细胞受体，我们提出，这种受体在眼部的存在也解释了人畜共患禽流感病毒（如1997年在香港出现的H5N1亚型、2003年在荷兰出现的H7N7、2003年在美国出现的H7N2以及2004年在加拿大出现的H7N3）所表现出的眼部嗜性。我们还提请注意这一假设可能对动物流行病和人畜共患流感以及未来大流行的引发产生的影响。
