Sakai K, Okuyama H, Yura J, Takeyama H, Shinagawa N, Tsuruga N, Kato K, Miura K, Kawase K, Tsujimura T
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Carcinogenesis. 1992 Apr;13(4):579-84. doi: 10.1093/carcin/13.4.579.
The phospholipid (PL) content was 4-fold higher while the triacylglycerol (TG) content tended to be 65% lower in human breast cancer tissues as compared with non-cancerous reference parts from excised breast tissues. The variation in TG content among breast tissues was very large while that of PL was relatively small. The fatty acid compositions of PL were significantly different between the cancer and reference tissues; the proportions of octadecenoate (18:1), docosahexaenoate (22:6n-3), the total n-3 fatty acids and the n-3/n-6 ratio, but not the proportion of arachidonate (20:4n-6), were significantly higher in the major PL of cancer tissues as compared with those of the reference tissues. No significant differences were observed in the proportion of the major fatty acids of TG in these tissues. The turnover of lipids was faster in the cancer tissues than in the reference tissues. The turnover of TG was faster than that of PL in the cancer tissues, whereas the opposite was true in the reference tissues, indicating significant differences in lipid metabolism between these tissues. A striking difference in the n-3 and n-6 fatty acids of the reference tissues noted for Japanese and Finnish women is discussed in relation to the roles of eicosanoids and eicosanoid precursors in mammary carcinogenesis.
与切除的乳腺组织中的非癌参考部分相比，人类乳腺癌组织中的磷脂（PL）含量高出4倍，而三酰甘油（TG）含量则往往低65%。乳腺组织中TG含量的变化非常大，而PL的变化相对较小。癌症组织和参考组织中PL的脂肪酸组成存在显著差异；与参考组织相比，癌症组织主要PL中十八碳烯酸（18:1）、二十二碳六烯酸（22:6n-3）、总n-3脂肪酸和n-3/n-6比值的比例显著更高，但花生四烯酸（20:4n-6）的比例没有显著差异。在这些组织中，TG主要脂肪酸的比例没有观察到显著差异。癌症组织中脂质的周转率比参考组织快。癌症组织中TG的周转率比PL快，而在参考组织中则相反，这表明这些组织之间脂质代谢存在显著差异。结合类二十烷酸和类二十烷酸前体在乳腺癌发生中的作用，讨论了日本和芬兰女性参考组织中n-3和n-6脂肪酸的显著差异。
