Blessing K, McLaren K M
Department of Pathology, Aberdeen University, Scotland, UK.
Histopathology. 1992 Apr;20(4):315-22. doi: 10.1111/j.1365-2559.1992.tb00988.x.
Five hundred and sixty-three primary cutaneous melanomas were assessed for the presence of histological regression in relation to the thickness of the lesion and features such as sex, anatomical location and clinical outcome. Regression was more common in thin lesions, being seen in 46% of thin (less than 1.5 mm) lesions, 32% of intermediate (1.5-3.0 mm) lesions and 9% of thick (greater than 3.0 mm) lesions. However, severe regression was only identified in 6.5% of thin lesions, 5.2% of intermediate lesions and 1.5% of thick melanomas. Regression was more common in superficial spreading melanomas and in lesions from the trunk and lower limb. Moderate and severe regression were seen slightly more often in men. Clinical follow-up, although not of statistical significance, suggests that regression in thin lesions is a sinister histological feature.
对563例原发性皮肤黑色素瘤进行评估，以确定组织学消退与病变厚度以及性别、解剖位置和临床结果等特征之间的关系。消退在薄病变中更为常见，在46%的薄（小于1.5mm）病变、32%的中等厚度（1.5 - 3.0mm）病变和9%的厚（大于3.0mm）病变中可见。然而，严重消退仅在6.5%的薄病变、5.2%的中等厚度病变和1.5%的厚黑色素瘤中被发现。消退在浅表扩散型黑色素瘤以及躯干和下肢的病变中更为常见。男性中出现中度和重度消退的情况略多。临床随访虽然无统计学意义，但表明薄病变中的消退是一种不祥的组织学特征。
